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Microtubule minus-end-targeting proteins.
Akhmanova A, Hoogenraad CC. Akhmanova A, et al. Curr Biol. 2015 Feb 16;25(4):R162-71. doi: 10.1016/j.cub.2014.12.027. Curr Biol. 2015. PMID: 25689915 Review.
Functional analysis of CLIP-115 and its binding to microtubules.
Hoogenraad CC, Akhmanova A, Grosveld F, De Zeeuw CI, Galjart N. Hoogenraad CC, et al. J Cell Sci. 2000 Jun;113 ( Pt 12):2285-97. J Cell Sci. 2000. PMID: 10825300
This head domain is connected to the C-terminal tail through a long coiled-coil structure. The MTB domains are conserved as a single domain in other proteins involved in microtubule based transport and dynamics, such as p150(Glued). ...
This head domain is connected to the C-terminal tail through a long coiled-coil structure. The MTB domains are conserved as a
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N. Akhmanova A, et al. Cell. 2001 Mar 23;104(6):923-35. doi: 10.1016/s0092-8674(01)00288-4. Cell. 2001. PMID: 11290329
Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.
Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N. Hoogenraad CC, et al. EMBO J. 2001 Aug 1;20(15):4041-54. doi: 10.1093/emboj/20.15.4041. EMBO J. 2001. PMID: 11483508 Free PMC article.
In interphase cells, BICD2 mainly localizes to the Golgi complex and has properties of a peripheral coat protein, yet it also co-localizes with dynactin at microtubule plus ends. ...Taken together, these data suggest that mammalian BICD2 plays a role in the dynein- …
In interphase cells, BICD2 mainly localizes to the Golgi complex and has properties of a peripheral coat protein, yet it also co-loca …
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N. Hoogenraad CC, et al. Nat Genet. 2002 Sep;32(1):116-27. doi: 10.1038/ng954. Epub 2002 Aug 26. Nat Genet. 2002. PMID: 12195424
Williams syndrome is a neurodevelopmental disorder caused by the hemizygous deletion of 1.6 Mb on human chromosome 7q11.23. This region comprises the gene CYLN2, encoding CLIP-115, a microtubule-binding protein of 115 kD. ...Absence of CLIP-115 also leads to increas …
Williams syndrome is a neurodevelopmental disorder caused by the hemizygous deletion of 1.6 Mb on human chromosome 7q11.23. This regi …
Cytoplasmic linker proteins promote microtubule rescue in vivo.
Komarova YA, Akhmanova AS, Kojima S, Galjart N, Borisy GG. Komarova YA, et al. J Cell Biol. 2002 Nov 25;159(4):589-99. doi: 10.1083/jcb.200208058. J Cell Biol. 2002. PMID: 12446741 Free PMC article.
We conclude that the CLIP head domain is sufficient to alter MT dynamics either by itself serving as a rescue factor or indirectly by recruiting a rescue factor. By promoting a high rescue frequency, CLIPs provide a mechanism by which MT plus ends may …
We conclude that the CLIP head domain is sufficient to alter MT dynamics either by itself serving as a rescue factor or indirectly by …
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).
Stepanova T, Slemmer J, Hoogenraad CC, Lansbergen G, Dortland B, De Zeeuw CI, Grosveld F, van Cappellen G, Akhmanova A, Galjart N. Stepanova T, et al. J Neurosci. 2003 Apr 1;23(7):2655-64. doi: 10.1523/JNEUROSCI.23-07-02655.2003. J Neurosci. 2003. PMID: 12684451 Free PMC article.
Using EB3-GFP as a marker of microtubule growth in live cells, we subsequently analyze microtubule dynamics in neurons. Our results indicate that microtubules grow slower in neurons than in glia and COS-1 cells. ...
Using EB3-GFP as a marker of microtubule growth in live cells, we subsequently analyze microtubule dynamics in neurons. Our results i …
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport.
Hoogenraad CC, Wulf P, Schiefermeier N, Stepanova T, Galjart N, Small JV, Grosveld F, de Zeeuw CI, Akhmanova A. Hoogenraad CC, et al. EMBO J. 2003 Nov 17;22(22):6004-15. doi: 10.1093/emboj/cdg592. EMBO J. 2003. PMID: 14609947 Free PMC article.
This characteristic offers a new tool to exploit the relocalization of different cellular components by using appropriate targeting motifs. ...Our findings provide a novel model system for dissection of the molecular mechanism of dynein motility....
This characteristic offers a new tool to exploit the relocalization of different cellular components by using appropriate targeting m …
LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome.
Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI. Hoogenraad CC, et al. Bioessays. 2004 Feb;26(2):141-50. doi: 10.1002/bies.10402. Bioessays. 2004. PMID: 14745832 Review.
Williams Syndrome is a developmental disorder that is characterized by cardiovascular problems, particular facial features and several typical behavioral and neurological abnormalities. In Williams Syndrome patients, a heterozygous deletion is present of a re …
Williams Syndrome is a developmental disorder that is characterized by cardiovascular problems, particular facial features and severa …
Thirteen is the lucky number for doublecortin.
Akhmanova A, Severin F. Akhmanova A, et al. Dev Cell. 2004 Jul;7(1):5-6. doi: 10.1016/j.devcel.2004.06.011. Dev Cell. 2004. PMID: 15239948 Review.
Doublecortin is a microtubule-associated protein that is essential for normal brain development. A recent report published in Molecular Cell shows that doublecortin associates preferentially with microtubules made of 13 protofilaments, by recognizing a novel …
Doublecortin is a microtubule-associated protein that is essential for normal brain development. A recent report published in …
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