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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.
Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB. Kirkpatrick CL, et al. Among authors: akhmedov d. J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22. J Biol Chem. 2011. PMID: 21784843 Free PMC article.
Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity.
Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina YA, Gibson M, Berglund ED, Justice NJ, Berdeaux R. Nixon M, et al. Among authors: akhmedov d. Mol Metab. 2015 Nov 6;5(1):34-46. doi: 10.1016/j.molmet.2015.10.004. eCollection 2016 Jan. Mol Metab. 2015. PMID: 26844205 Free PMC article.
Regulation of SIK1 abundance and stability is critical for myogenesis.
Stewart R, Akhmedov D, Robb C, Leiter C, Berdeaux R. Stewart R, et al. Among authors: akhmedov d. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):117-22. doi: 10.1073/pnas.1212676110. Epub 2012 Dec 19. Proc Natl Acad Sci U S A. 2013. PMID: 23256157 Free PMC article.
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