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99 results
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Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C.
Akinaga S, Nomura K, Gomi K, Okabe M. Akinaga S, et al. Cancer Chemother Pharmacol. 1993;32(3):183-9. doi: 10.1007/BF00685833. Cancer Chemother Pharmacol. 1993. PMID: 8500222
Engineered therapeutic antibodies with improved effector functions.
Kubota T, Niwa R, Satoh M, Akinaga S, Shitara K, Hanai N. Kubota T, et al. Among authors: akinaga s. Cancer Sci. 2009 Sep;100(9):1566-72. doi: 10.1111/j.1349-7006.2009.01222.x. Epub 2009 May 18. Cancer Sci. 2009. PMID: 19538497 Review.
Phase I study of highly selective inhibitor of VEGFR tyrosine kinase, tivozanib, in Japanese patients with solid tumors.
Niwakawa M, Yamaguchi R, Onozawa Y, Yasui H, Taku K, Naito T, Akinaga S, Boku N, Yamamoto N. Niwakawa M, et al. Among authors: akinaga s. Cancer Sci. 2013 Aug;104(8):1039-44. doi: 10.1111/cas.12197. Epub 2013 Jun 21. Cancer Sci. 2013. PMID: 23679664 Free PMC article. Clinical Trial.
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation.
Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, Ishii K, Mori Y, Ozeki K, Minami Y, Abe A, Maeda H, Akiyama T, Kanda Y, Sato Y, Akinaga S, Naoe T. Shiotsu Y, et al. Among authors: akinaga s. Blood. 2009 Aug 20;114(8):1607-17. doi: 10.1182/blood-2009-01-199307. Epub 2009 Jun 18. Blood. 2009. PMID: 19541823
A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo.
Shimada N, Ishii T, Imada T, Takaba K, Sasaki Y, Maruyama-Takahashi K, Maekawa-Tokuda Y, Kusaka H, Akinaga S, Tanaka A, Shitara K. Shimada N, et al. Among authors: akinaga s. Clin Cancer Res. 2005 May 15;11(10):3897-904. doi: 10.1158/1078-0432.CCR-04-2358. Clin Cancer Res. 2005. PMID: 15897591
A novel telomerase template antagonist (GRN163) as a potential anticancer agent.
Asai A, Oshima Y, Yamamoto Y, Uochi TA, Kusaka H, Akinaga S, Yamashita Y, Pongracz K, Pruzan R, Wunder E, Piatyszek M, Li S, Chin AC, Harley CB, Gryaznov S. Asai A, et al. Among authors: akinaga s. Cancer Res. 2003 Jul 15;63(14):3931-9. Cancer Res. 2003. PMID: 12873987
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients.
Nakata T, Takashima S, Shiotsu Y, Murakata C, Ishida H, Akinaga S, Li PK, Sasano H, Suzuki T, Saeki T. Nakata T, et al. Among authors: akinaga s. J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):455-60. doi: 10.1016/s0960-0760(03)00357-1. J Steroid Biochem Mol Biol. 2003. PMID: 14623544
Improved formulations of antisense oligodeoxynucleotides using wrapped liposomes.
Yamauchi M, Kusano H, Saito E, Iwata T, Nakakura M, Kato Y, Uochi T, Akinaga S, Aoki N. Yamauchi M, et al. Among authors: akinaga s. J Control Release. 2006 Aug 28;114(2):268-75. doi: 10.1016/j.jconrel.2006.05.025. Epub 2006 Jun 6. J Control Release. 2006. PMID: 16860428
Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo.
Ishida H, Nakata T, Sato N, Li PK, Kuwabara T, Akinaga S. Ishida H, et al. Among authors: akinaga s. Breast Cancer Res Treat. 2007 Aug;104(2):211-9. doi: 10.1007/s10549-006-9404-8. Epub 2006 Oct 24. Breast Cancer Res Treat. 2007. PMID: 17061037
New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells.
Nakashima T, Ishii T, Tagaya H, Seike T, Nakagawa H, Kanda Y, Akinaga S, Soga S, Shiotsu Y. Nakashima T, et al. Among authors: akinaga s. Clin Cancer Res. 2010 May 15;16(10):2792-802. doi: 10.1158/1078-0432.CCR-09-3112. Epub 2010 Apr 20. Clin Cancer Res. 2010. PMID: 20406843
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