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1,268 results
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Signaling to NF-kappaB by Toll-like receptors.
Kawai T, Akira S. Kawai T, et al. Among authors: akira s. Trends Mol Med. 2007 Nov;13(11):460-9. doi: 10.1016/j.molmed.2007.09.002. Epub 2007 Oct 29. Trends Mol Med. 2007. PMID: 18029230 Review.
Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.
Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J. Yamazaki K, et al. Among authors: akira s. Sci Signal. 2009 Oct 20;2(93):ra66. doi: 10.1126/scisignal.2000387. Sci Signal. 2009. PMID: 19843958
Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T. Kitai Y, et al. Among authors: akira s. J Biol Chem. 2015 Jan 9;290(2):1269-80. doi: 10.1074/jbc.M114.611053. Epub 2014 Dec 1. J Biol Chem. 2015. PMID: 25451939 Free PMC article.
Viral infections activate types I and III interferon genes through a common mechanism.
Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T. Onoguchi K, et al. Among authors: akira s. J Biol Chem. 2007 Mar 9;282(10):7576-81. doi: 10.1074/jbc.M608618200. Epub 2007 Jan 4. J Biol Chem. 2007. PMID: 17204473
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S. Bhattacharjee RN, et al. Among authors: akira s. J Biol Chem. 2006 Dec 1;281(48):36897-904. doi: 10.1074/jbc.M605493200. Epub 2006 Sep 19. J Biol Chem. 2006. PMID: 16984916
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.
Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J. Huangfu WC, et al. Among authors: akira s. J Biol Chem. 2006 Sep 29;281(39):28802-10. doi: 10.1074/jbc.M603627200. Epub 2006 Aug 7. J Biol Chem. 2006. PMID: 16893890 Free PMC article.
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J. Uemura N, et al. Among authors: akira s. J Biol Chem. 2006 Mar 24;281(12):7863-72. doi: 10.1074/jbc.M509834200. Epub 2006 Jan 30. J Biol Chem. 2006. PMID: 16446357 Free PMC article.
Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.
Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C. Inada M, et al. Among authors: akira s. J Biol Chem. 2015 Dec 11;290(50):29781-93. doi: 10.1074/jbc.M115.669481. Epub 2015 Oct 16. J Biol Chem. 2015. PMID: 26475855 Free PMC article.
TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent.
Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X. Qin J, et al. Among authors: akira s. J Biol Chem. 2006 Jul 28;281(30):21013-21. doi: 10.1074/jbc.M512908200. Epub 2006 May 31. J Biol Chem. 2006. PMID: 16737960
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T. Kuniyoshi K, et al. Among authors: akira s. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51. doi: 10.1073/pnas.1401674111. Epub 2014 Mar 27. Proc Natl Acad Sci U S A. 2014. PMID: 24706898 Free PMC article.
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