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Innate immunity to virus infection.
Takeuchi O, Akira S. Takeuchi O, et al. Immunol Rev. 2009 Jan;227(1):75-86. doi: 10.1111/j.1600-065X.2008.00737.x. Immunol Rev. 2009. PMID: 19120477 Free PMC article. Review.
5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S. Maruyama K, et al. J Biol Chem. 2015 Apr 10;290(15):9377-86. doi: 10.1074/jbc.M114.631374. Epub 2015 Feb 17. J Biol Chem. 2015. PMID: 25691576 Free PMC article.
Negative regulation of melanoma differentiation-associated gene 5 (MDA5)-dependent antiviral innate immune responses by Arf-like protein 5B.
Kitai Y, Takeuchi O, Kawasaki T, Ori D, Sueyoshi T, Murase M, Akira S, Kawai T. Kitai Y, et al. J Biol Chem. 2015 Jan 9;290(2):1269-80. doi: 10.1074/jbc.M114.611053. Epub 2014 Dec 1. J Biol Chem. 2015. PMID: 25451939 Free PMC article.
Influenza A virus polymerase inhibits type I interferon induction by binding to interferon beta promoter stimulator 1.
Iwai A, Shiozaki T, Kawai T, Akira S, Kawaoka Y, Takada A, Kida H, Miyazaki T. Iwai A, et al. J Biol Chem. 2010 Oct 15;285(42):32064-74. doi: 10.1074/jbc.M110.112458. Epub 2010 Aug 10. J Biol Chem. 2010. PMID: 20699220 Free PMC article.
TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T. Yoshida R, et al. J Biol Chem. 2008 Dec 26;283(52):36211-20. doi: 10.1074/jbc.M806576200. Epub 2008 Nov 4. J Biol Chem. 2008. PMID: 18984593 Free PMC article.
Viral infections activate types I and III interferon genes through a common mechanism.
Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H, Fujita T. Onoguchi K, et al. J Biol Chem. 2007 Mar 9;282(10):7576-81. doi: 10.1074/jbc.M608618200. Epub 2007 Jan 4. J Biol Chem. 2007. PMID: 17204473
Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity.
Kuniyoshi K, Takeuchi O, Pandey S, Satoh T, Iwasaki H, Akira S, Kawai T. Kuniyoshi K, et al. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51. doi: 10.1073/pnas.1401674111. Epub 2014 Mar 27. Proc Natl Acad Sci U S A. 2014. PMID: 24706898 Free PMC article.
Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus.
Lee H, Komano J, Saitoh Y, Yamaoka S, Kozaki T, Misawa T, Takahama M, Satoh T, Takeuchi O, Yamamoto N, Matsuura Y, Saitoh T, Akira S. Lee H, et al. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12379-84. doi: 10.1073/pnas.1310604110. Epub 2013 Jul 8. Proc Natl Acad Sci U S A. 2013. PMID: 23836649 Free PMC article.
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S, Kawai T. Kondo T, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2969-74. doi: 10.1073/pnas.1222694110. Epub 2013 Feb 6. Proc Natl Acad Sci U S A. 2013. PMID: 23388631 Free PMC article.
IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.
Miyake T, Satoh T, Kato H, Matsushita K, Kumagai Y, Vandenbon A, Tani T, Muta T, Akira S, Takeuchi O. Miyake T, et al. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17680-5. doi: 10.1073/pnas.1012977107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876105 Free PMC article.
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