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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi O, Kawai T, Takeda K, Matsumoto M, Tsutsui H, Sakagami M, Nakanishi K, Akira S. Adachi O, et al. Immunity. 1998 Jul;9(1):143-50. doi: 10.1016/s1074-7613(00)80596-8. Immunity. 1998. PMID: 9697844
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K. Adachi K, et al. J Immunol. 2001 Nov 15;167(10):5928-34. doi: 10.4049/jimmunol.167.10.5928. J Immunol. 2001. PMID: 11698470
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.
Seki E, Tsutsui H, Nakano H, Tsuji N, Hoshino K, Adachi O, Adachi K, Futatsugi S, Kuida K, Takeuchi O, Okamura H, Fujimoto J, Akira S, Nakanishi K. Seki E, et al. J Immunol. 2001 Feb 15;166(4):2651-7. doi: 10.4049/jimmunol.166.4.2651. J Immunol. 2001. PMID: 11160328
Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice.
Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S. Kaisho T, et al. J Exp Med. 1999 Dec 6;190(11):1573-82. doi: 10.1084/jem.190.11.1573. J Exp Med. 1999. PMID: 10587348 Free PMC article.
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.
Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K. Yoshimoto T, et al. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13962-6. doi: 10.1073/pnas.96.24.13962. Proc Natl Acad Sci U S A. 1999. PMID: 10570181 Free PMC article.
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases.
Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S. Shimada T, et al. Int Immunol. 1999 Aug;11(8):1357-62. doi: 10.1093/intimm/11.8.1357. Int Immunol. 1999. PMID: 10421793
Functional roles of STAT family proteins: lessons from knockout mice.
Akira S. Akira S. Stem Cells. 1999;17(3):138-46. doi: 10.1002/stem.170138. Stem Cells. 1999. PMID: 10342556 Review.
IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor.
Hyodo Y, Matsui K, Hayashi N, Tsutsui H, Kashiwamura S, Yamauchi H, Hiroishi K, Takeda K, Tagawa Y, Iwakura Y, Kayagaki N, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, Nakanishi K, Higashino K. Hyodo Y, et al. J Immunol. 1999 Feb 1;162(3):1662-8. J Immunol. 1999. PMID: 9973427
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