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Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.
Ashrafian H, Czibik G, Bellahcene M, Aksentijević D, Smith AC, Mitchell SJ, Dodd MS, Kirwan J, Byrne JJ, Ludwig C, Isackson H, Yavari A, Støttrup NB, Contractor H, Cahill TJ, Sahgal N, Ball DR, Birkler RI, Hargreaves I, Tennant DA, Land J, Lygate CA, Johannsen M, Kharbanda RK, Neubauer S, Redwood C, de Cabo R, Ahmet I, Talan M, Günther UL, Robinson AJ, Viant MR, Pollard PJ, Tyler DJ, Watkins H. Ashrafian H, et al. Among authors: aksentijevic d. Cell Metab. 2012 Mar 7;15(3):361-71. doi: 10.1016/j.cmet.2012.01.017. Cell Metab. 2012. PMID: 22405071 Free PMC article.
Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.
Lygate CA, Medway DJ, Ostrowski PJ, Aksentijevic D, Sebag-Montefiore L, Hunyor I, Zervou S, Schneider JE, Neubauer S. Lygate CA, et al. Among authors: aksentijevic d. Basic Res Cardiol. 2012 Sep;107(5):276. doi: 10.1007/s00395-012-0276-2. Epub 2012 Jul 4. Basic Res Cardiol. 2012. PMID: 22760499 Free PMC article.
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction.
Lygate CA, Bohl S, ten Hove M, Faller KM, Ostrowski PJ, Zervou S, Medway DJ, Aksentijevic D, Sebag-Montefiore L, Wallis J, Clarke K, Watkins H, Schneider JE, Neubauer S. Lygate CA, et al. Among authors: aksentijevic d. Cardiovasc Res. 2012 Dec 1;96(3):466-75. doi: 10.1093/cvr/cvs272. Epub 2012 Aug 21. Cardiovasc Res. 2012. PMID: 22915766 Free PMC article.
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.
Lygate CA, Aksentijevic D, Dawson D, ten Hove M, Phillips D, de Bono JP, Medway DJ, Sebag-Montefiore L, Hunyor I, Channon KM, Clarke K, Zervou S, Watkins H, Balaban RS, Neubauer S. Lygate CA, et al. Among authors: aksentijevic d. Circ Res. 2013 Mar 15;112(6):945-55. doi: 10.1161/CIRCRESAHA.112.300725. Epub 2013 Jan 16. Circ Res. 2013. PMID: 23325497 Free PMC article.
Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts.
Branovets J, Sepp M, Kotlyarova S, Jepihhina N, Sokolova N, Aksentijevic D, Lygate CA, Neubauer S, Vendelin M, Birkedal R. Branovets J, et al. Among authors: aksentijevic d. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H506-20. doi: 10.1152/ajpheart.00919.2012. Epub 2013 Jun 21. Am J Physiol Heart Circ Physiol. 2013. PMID: 23792673 Free PMC article.
Cardiac dysfunction and peri-weaning mortality in malonyl-coenzyme A decarboxylase (MCD) knockout mice as a consequence of restricting substrate plasticity.
Aksentijević D, McAndrew DJ, Karlstädt A, Zervou S, Sebag-Montefiore L, Cross R, Douglas G, Regitz-Zagrosek V, Lopaschuk GD, Neubauer S, Lygate CA. Aksentijević D, et al. J Mol Cell Cardiol. 2014 Oct;75:76-87. doi: 10.1016/j.yjmcc.2014.07.008. Epub 2014 Jul 24. J Mol Cell Cardiol. 2014. PMID: 25066696 Free PMC article.
Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine.
Faller KME, Atzler D, McAndrew DJ, Zervou S, Whittington HJ, Simon JN, Aksentijevic D, Ten Hove M, Choe CU, Isbrandt D, Casadei B, Schneider JE, Neubauer S, Lygate CA. Faller KME, et al. Among authors: aksentijevic d. Cardiovasc Res. 2018 Mar 1;114(3):417-430. doi: 10.1093/cvr/cvx242. Cardiovasc Res. 2018. PMID: 29236952 Free PMC article.
42 results