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Design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as potential SPECT ligands for the 5-HT1A receptor.
J Med Chem. 2011 May 26;54(10):3480-91. doi: 10.1021/jm1009956. Epub 2011 Apr 26.
J Med Chem. 2011.
PMID: 21520940
Design, synthesis and in vitro evaluation of bridgehead fluoromethyl analogs of N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) for the 5-HT(1A) receptor.
Al Hussainy R, Verbeek J, van der Born D, Booij J, Herscheid JK.
Al Hussainy R, et al.
Eur J Med Chem. 2011 Dec;46(12):5728-35. doi: 10.1016/j.ejmech.2011.06.023. Epub 2011 Jun 29.
Eur J Med Chem. 2011.
PMID: 22000209
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Synthesis, biodistribution and PET studies in rats of (18)F-Labeled bridgehead fluoromethyl analogues of WAY-100635.
Al Hussainy R, Verbeek J, van der Born D, Molthoff C, Booij J, Herscheid JK.
Al Hussainy R, et al.
Nucl Med Biol. 2012 Oct;39(7):1068-76. doi: 10.1016/j.nucmedbio.2012.04.002. Epub 2012 May 17.
Nucl Med Biol. 2012.
PMID: 22609028
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