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First report of Neofusicoccum australe causing dieback of honeybush in the Western Cape, South Africa.
Halleen F, Havenga M, McLeod A, Mostert L. Halleen F, et al. Plant Dis. 2022 Aug 15. doi: 10.1094/PDIS-06-22-1429-PDN. Online ahead of print. Plant Dis. 2022. PMID: 35971263
Smit, L. et al. 2021. Eur. J. Plant Pathol. 161:565. van Niekerk, J. M. et al. 2004. Mycologia 96:781. White, T. J. et al. 1990. Pages 315 in: In PCR Protocols: A Guide to Methods and Applications. ...
Smit, L. et al. 2021. Eur. J. Plant Pathol. 161:565. van Niekerk, J. M. et al. 2004. Mycologia 96:781. White, T. J. et …
Evaluating the Link Between Self-Reported Endometriosis and Female Sexual Dysfunction.
Kling JM, Ghaith S, Smith T, Kapoor E, Wasson M, Mara K, Enders FT, Faubion S, Kuhle C. Kling JM, et al. J Sex Med. 2022 Aug 12:S1743-6095(22)01543-0. doi: 10.1016/j.jsxm.2022.07.009. Online ahead of print. J Sex Med. 2022. PMID: 35970712
Endometriosis increased the odds of FSD only in premenopausal women. Kling JM, Ghaith S, Smith T, et al. Evaluating the Link Between Self-Reported Endometriosis and Female Sexual Dysfunction. ...
Endometriosis increased the odds of FSD only in premenopausal women. Kling JM, Ghaith S, Smith T, et al. Evaluating the Link B …
Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.
Grover S, Kumar Sreelatha AA, Pihlstrom L, Domenighetti C, Schulte C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Mohamed O, Portugal B, Landoulsi Z, May P, Bobbili D, Edsall C, Bartusch F, Hanussek M, Krüger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla LF, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Pavelka L, van de Warrenburg BPC, Bloem BR, Singleton AB, Aasly J, Toft M, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Kruger R, Elbaz A, Gasser T, Sharma M; and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD) Consortium. Grover S, et al. Neurology. 2022 Aug 16;99(7):e698-e710. doi: 10.1212/WNL.0000000000200699. Epub 2022 May 26. Neurology. 2022. PMID: 35970579
Targeting CRAC channels in inflammatory bowel disease.
Kappel S, Peinelt C. Kappel S, et al. EMBO Mol Med. 2022 Aug 15:e16489. doi: 10.15252/emmm.202216489. Online ahead of print. EMBO Mol Med. 2022. PMID: 35969215
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases of the human gastrointestinal (GI) tract that are characterized by perturbations in the intestinal immune responses. In their study, Letizia et al (2022) found an enrichment of CD4(+) effector …
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases of the human gastrointestinal (GI) tract that are characteri …
Supercharged chimeric antigen receptor T cells in solid tumors.
Pant A, Jackson CM. Pant A, et al. J Clin Invest. 2022 Aug 15;132(16):e162322. doi: 10.1172/JCI162322. J Clin Invest. 2022. PMID: 35968786
Challenges specific to treating solid tumors include trafficking and distribution throughout the tumor site, overcoming the immunosuppressive tumor microenvironment (TME), and identifying antigenic targets that are widely expressed and indispensable to tumor biology. In this issu …
Challenges specific to treating solid tumors include trafficking and distribution throughout the tumor site, overcoming the immunosuppressiv …
Multiple myeloma with t(11;14): unique biology and evolving landscape.
Bal S, Kumar SK, Fonseca R, Gay F, Hungria VT, Dogan A, Costa LJ. Bal S, et al. Am J Cancer Res. 2022 Jul 15;12(7):2950-2965. eCollection 2022. Am J Cancer Res. 2022. PMID: 35968339 Free PMC article. Review.
Multiple myeloma harboring t(11;14) represents a unique disease subset as t(11;14)-positive myeloma cells exhibit biological features that are distinct from t(11;14)-negative myeloma cells, including overexpression of cyclin D1, higher levels of the antiapopt …
Multiple myeloma harboring t(11;14) represents a unique disease subset as t(11;14)-positive myeloma cells exhibit biological f …
PERK promotes immunosuppressive M2 macrophage phenotype by metabolic reprogramming and epigenetic modifications through the PERK-ATF4-PSAT1 axis.
Pratap UP, Vadlamudi RK. Pratap UP, et al. Immunometabolism (Cobham). 2022 Jul 29;4(3):e00007. doi: 10.1097/IN9.0000000000000007. eCollection 2022 Jul. Immunometabolism (Cobham). 2022. PMID: 35966637 Free PMC article.
To overcome these conditions, cells activate ER stress response pathways, which are shown to augment the suppressive phenotypes of immune cells; however, the molecular mechanisms underpinning this process remain elusive. Here, we discuss a recent study by Raines et al, tha …
To overcome these conditions, cells activate ER stress response pathways, which are shown to augment the suppressive phenotypes of immune ce …
Helping the helpers: polyamines help maintain helper T-cell lineage fidelity.
Stewart TM, Holbert CE, Casero RA Jr. Stewart TM, et al. Immunometabolism (Cobham). 2022 Aug 5;4(3):e00002. doi: 10.1097/IN9.0000000000000002. eCollection 2022 Jul. Immunometabolism (Cobham). 2022. PMID: 35966633 Free PMC article.
The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems and analytical tools necessary to evaluate their roles have become available. Puleston et al have recently demonstrated that polyamine …
The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems a …
Residual Bone Marrow T & NK-Cells at Diagnosis in Pediatric Pre-B-ALL: A Case-Control Study.
Eldewi DM, El-Hagrasy HA, Gouda RM, Hassan MAEM, Kamel SM, Abd El Haliem NF, Anani HAA. Eldewi DM, et al. Int J Gen Med. 2022 Aug 7;15:6475-6483. doi: 10.2147/IJGM.S375991. eCollection 2022. Int J Gen Med. 2022. PMID: 35966509 Free PMC article.
OBJECTIVE: We aimed to assess the percentage of the residual BM T-cells, (T-helper -T-cytotoxic- NKT) and the NK cells of childhood precursor B-lymphoblastic leukemia (B-ALL) as an indicator of innate and adaptive immunity in these patients. ...The flow cytom …
OBJECTIVE: We aimed to assess the percentage of the residual BM T-cells, (T-helper -T-cytotoxic- NKT) and the NK cells …
Detection of erythroid progenitors and erythrocytopathies in patients with severe COVID-19 disease.
Allahyani MA, Aljuaid AA, Almehmadi MM, Alghamdi AA, Halawani IF, Aldairi AF, Alharbi AM, Albshri MH, Mutwalli AA, Alhazmi AS. Allahyani MA, et al. Saudi Med J. 2022 Aug;43(8):899-906. doi: 10.15537/smj.2022.43.8.20220311. Saudi Med J. 2022. PMID: 35964959
The expression of CD235a, CD71, and CD36 was obtained using flow cytometry technique. The unpaired t-test was conducted to evaluate the differences in these markers in COVID-19 patients and healthy individuals. ...
The expression of CD235a, CD71, and CD36 was obtained using flow cytometry technique. The unpaired t-test was conducted to evaluate t …
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