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Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism.
Al Koudsi N, Tyndale RF. Al Koudsi N, et al. Xenobiotica. 2010 Jun;40(6):381-92. doi: 10.3109/00498251003713958. Xenobiotica. 2010. PMID: 20307138
Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers.
Ho MK, Mwenifumbo JC, Al Koudsi N, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. Ho MK, et al. Among authors: al koudsi n. Clin Pharmacol Ther. 2009 Jun;85(6):635-43. doi: 10.1038/clpt.2009.19. Epub 2009 Mar 11. Clin Pharmacol Ther. 2009. PMID: 19279561 Free PMC article. Clinical Trial.
Genetic influences on smoking: a brief review.
Al Koudsi N, Tyndale RF. Al Koudsi N, et al. Ther Drug Monit. 2005 Dec;27(6):704-9. doi: 10.1097/01.ftd.0000179842.63515.c6. Ther Drug Monit. 2005. PMID: 16404798 Review.
Characterization of the novel CYP2A6*21 allele using in vivo nicotine kinetics.
Al Koudsi N, Mwenifumbo JC, Sellers EM, Benowitz NL, Swan GE, Tyndale RF. Al Koudsi N, et al. Eur J Clin Pharmacol. 2006 Jun;62(6):481-4. doi: 10.1007/s00228-006-0113-3. Epub 2006 Apr 28. Eur J Clin Pharmacol. 2006. PMID: 16758265
Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors.
Al Koudsi N, Hoffmann EB, Assadzadeh A, Tyndale RF. Al Koudsi N, et al. Eur J Clin Pharmacol. 2010 Mar;66(3):239-51. doi: 10.1007/s00228-009-0762-0. Epub 2009 Dec 9. Eur J Clin Pharmacol. 2010. PMID: 20012030 Free PMC article.
A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.
Al Koudsi N, Ahluwalia JS, Lin SK, Sellers EM, Tyndale RF. Al Koudsi N, et al. Pharmacogenomics J. 2009 Aug;9(4):274-82. doi: 10.1038/tpj.2009.11. Epub 2009 Apr 14. Pharmacogenomics J. 2009. PMID: 19365400 Free PMC article.
The role of CYP2A6 in the emergence of nicotine dependence in adolescents.
Audrain-McGovern J, Al Koudsi N, Rodriguez D, Wileyto EP, Shields PG, Tyndale RF. Audrain-McGovern J, et al. Among authors: al koudsi n. Pediatrics. 2007 Jan;119(1):e264-74. doi: 10.1542/peds.2006-1583. Epub 2006 Nov 27. Pediatrics. 2007. PMID: 17130279
Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.
Mwenifumbo JC, Al Koudsi N, Ho MK, Zhou Q, Hoffmann EB, Sellers EM, Tyndale RF. Mwenifumbo JC, et al. Among authors: al koudsi n. Hum Mutat. 2008 May;29(5):679-88. doi: 10.1002/humu.20698. Hum Mutat. 2008. PMID: 18360915
In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury.
Guo J, Dhaliwall JK, Chan KK, Ghanim H, Al Koudsi N, Lam L, Madadi G, Dandona P, Giacca A, Bendeck MP. Guo J, et al. Among authors: al koudsi n. J Vasc Res. 2013;50(4):279-88. doi: 10.1159/000351611. Epub 2013 Jul 9. J Vasc Res. 2013. PMID: 23988659
Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury.
Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A. Breen DM, et al. Among authors: al koudsi n. Arterioscler Thromb Vasc Biol. 2009 Jul;29(7):1060-6. doi: 10.1161/ATVBAHA.109.185447. Epub 2009 Apr 9. Arterioscler Thromb Vasc Biol. 2009. PMID: 19359661
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