Ala P - Search Results

1

Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.

Jadhav PK, Ala P, Woerner FJ, Chang CH, Garber SS, Anton ED, Bacheler LT. Jadhav PK, et al. Among authors: ala p. J Med Chem. 1997 Jan 17;40(2):181-91. doi: 10.1021/jm960586t. J Med Chem. 1997. PMID: 9003516

2

Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.

Douty B, Wayland B, Ala PJ, Bower MJ, Pruitt J, Bostrom L, Wei M, Klabe R, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP, Yue EW. Douty B, et al. Among authors: ala pj. Bioorg Med Chem Lett. 2008 Jan 1;18(1):66-71. doi: 10.1016/j.bmcl.2007.11.012. Epub 2007 Nov 9. Bioorg Med Chem Lett. 2008. PMID: 18037290

3

Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors.

Sparks RB, Polam P, Zhu W, Crawley ML, Takvorian A, McLaughlin E, Wei M, Ala PJ, Gonneville L, Taylor N, Li Y, Wynn R, Burn TC, Liu PC, Combs AP. Sparks RB, et al. Among authors: ala pj. Bioorg Med Chem Lett. 2007 Feb 1;17(3):736-40. doi: 10.1016/j.bmcl.2006.10.079. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17097290

4

Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B.

Ala PJ, Gonneville L, Hillman M, Becker-Pasha M, Yue EW, Douty B, Wayland B, Polam P, Crawley ML, McLaughlin E, Sparks RB, Glass B, Takvorian A, Combs AP, Burn TC, Hollis GF, Wynn R. Ala PJ, et al. J Biol Chem. 2006 Dec 8;281(49):38013-21. doi: 10.1074/jbc.M607913200. Epub 2006 Oct 6. J Biol Chem. 2006. PMID: 17028182

5

Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics.

Ala PJ, Gonneville L, Hillman MC, Becker-Pasha M, Wei M, Reid BG, Klabe R, Yue EW, Wayland B, Douty B, Polam P, Wasserman Z, Bower M, Combs AP, Burn TC, Hollis GF, Wynn R. Ala PJ, et al. J Biol Chem. 2006 Oct 27;281(43):32784-95. doi: 10.1074/jbc.M606873200. Epub 2006 Aug 17. J Biol Chem. 2006. PMID: 16916797

6

Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic.

Combs AP, Zhu W, Crawley ML, Glass B, Polam P, Sparks RB, Modi D, Takvorian A, McLaughlin E, Yue EW, Wasserman Z, Bower M, Wei M, Rupar M, Ala PJ, Reid BM, Ellis D, Gonneville L, Emm T, Taylor N, Yeleswaram S, Li Y, Wynn R, Burn TC, Hollis G, Liu PC, Metcalf B. Combs AP, et al. Among authors: ala pj. J Med Chem. 2006 Jun 29;49(13):3774-89. doi: 10.1021/jm0600904. J Med Chem. 2006. PMID: 16789735

7

Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.

Combs AP, Yue EW, Bower M, Ala PJ, Wayland B, Douty B, Takvorian A, Polam P, Wasserman Z, Zhu W, Crawley ML, Pruitt J, Sparks R, Glass B, Modi D, McLaughlin E, Bostrom L, Li M, Galya L, Blom K, Hillman M, Gonneville L, Reid BG, Wei M, Becker-Pasha M, Klabe R, Huber R, Li Y, Hollis G, Burn TC, Wynn R, Liu P, Metcalf B. Combs AP, et al. Among authors: ala pj. J Med Chem. 2005 Oct 20;48(21):6544-8. doi: 10.1021/jm0504555. J Med Chem. 2005. PMID: 16220970

8

Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: synthesis and structure-activity relationships of a peptide scaffold.

Yue EW, Wayland B, Douty B, Crawley ML, McLaughlin E, Takvorian A, Wasserman Z, Bower MJ, Wei M, Li Y, Ala PJ, Gonneville L, Wynn R, Burn TC, Liu PC, Combs AP. Yue EW, et al. Among authors: ala pj. Bioorg Med Chem. 2006 Sep 1;14(17):5833-49. doi: 10.1016/j.bmc.2006.05.032. Bioorg Med Chem. 2006. PMID: 16769216

9

Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.

Ala PJ, Huston EE, Klabe RM, Jadhav PK, Lam PY, Chang CH. Ala PJ, et al. Biochemistry. 1998 Oct 27;37(43):15042-9. doi: 10.1021/bi980386e. Biochemistry. 1998. PMID: 9790666

10

Resistance to HIV protease inhibitors: a comparison of enzyme inhibition and antiviral potency.

Klabe RM, Bacheler LT, Ala PJ, Erickson-Viitanen S, Meek JL. Klabe RM, et al. Among authors: ala pj. Biochemistry. 1998 Jun 16;37(24):8735-42. doi: 10.1021/bi972555l. Biochemistry. 1998. PMID: 9628735

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