Neurologic changes can be seen during treatment for hematologic malignancies such as lymphoma and leukemia. Differential diagnoses for neurologic changes remain vast, and etiologies may result from malignant, nonmalignant, and paraneoplastic syndromes. This article describes a case study of a man with neurolymphomatosis, a rare neurologic manifestation seen in B-cell and non-Hodgkin lymphoma and acute leukemias.