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1985 1
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1994 1
1995 1
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2001 1
2003 4
2005 2
2008 2
2011 1
2012 1
2013 2
2014 1
2015 2
2017 1
2018 1
2019 3
2020 4
2021 0
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Diabetic Kidney Disease: Diagnosis, Treatment, and Prevention.
McGrath K, Edi R. McGrath K, et al. Am Fam Physician. 2019 Jun 15;99(12):751-759. Am Fam Physician. 2019. PMID: 31194487 Free article.
DKD is associated with higher cardiovascular and all-cause morbidity and mortality, so timely diagnosis and treatment are critical. Screening for early DKD is best done with annual spot urine albumin/creatinine ratio testing, and diagnosis is confirmed by repeated elevatio …
DKD is associated with higher cardiovascular and all-cause morbidity and mortality, so timely diagnosis and treatment are critical. Screenin …
Profibrotic Circulating Proteins and Risk of Early Progressive Renal Decline in Patients With Type 2 Diabetes With and Without Albuminuria.
Ihara K, Skupien J, Kobayashi H, Md Dom ZI, Wilson JM, O'Neil K, Badger HS, Bowsman LM, Satake E, Breyer MD, Duffin KL, Krolewski AS. Ihara K, et al. Diabetes Care. 2020 Nov;43(11):2760-2767. doi: 10.2337/dc20-0630. Epub 2020 Sep 4. Diabetes Care. 2020. PMID: 32887710
RESEARCH DESIGN AND METHODS: Individuals with type 2 diabetes enrolled in the Joslin Kidney Study with an estimated glomerular filtration rate (eGFR) 60 mL/min/1.73 m(2) were monitored for 6-12 years to ascertain fast early progressive renal decline, defined as eGFR loss 5 mL/min …
RESEARCH DESIGN AND METHODS: Individuals with type 2 diabetes enrolled in the Joslin Kidney Study with an estimated glomerular filtration ra …
Albuminuria Testing by Race and Ethnicity among Patients with Hypertension with and without Diabetes.
Lee J, Chu C, Guzman D, Fontil V, Velasquez A, Powe NR, Tuot DS. Lee J, et al. Am J Nephrol. 2019;50(1):48-54. doi: 10.1159/000500706. Epub 2019 Jun 5. Am J Nephrol. 2019. PMID: 31167180 Free PMC article.
Logistic regression was used to identify odds of UACR testing within 1 year of a HTN diagnosis, overall, and by racial/ethnic subgroup, adjusted for demographic factors, estimated glomerular filtration rate, and HTN severity. ...RESULTS: The cohort (n = 16,414) was raciall …
Logistic regression was used to identify odds of UACR testing within 1 year of a HTN diagnosis, overall, and by racial/ethnic subgrou …
Low erythropoietin levels predict faster renal function decline in diabetic patients with anemia: a prospective cohort study.
Fujita Y, Doi Y, Hamano T, Hatazaki M, Umayahara Y, Isaka Y, Tsubakihara Y. Fujita Y, et al. Sci Rep. 2019 Oct 16;9(1):14871. doi: 10.1038/s41598-019-51207-8. Sci Rep. 2019. PMID: 31619722 Free PMC article.
Multivariable analysis revealed that iron status and hemoglobin levels were major determinants of EPO levels. Median eGFR slope was -1.3 mL/min/1.73 m(2)/year. We found that low EPO levels, but not low hemoglobin levels, were associated with a faster decline in eGFR, indep …
Multivariable analysis revealed that iron status and hemoglobin levels were major determinants of EPO levels. Median eGFR slope was -1.3 mL/ …
Plasma osteoprotegerin as a biomarker of poor glycaemic control that predicts progression of albuminuria in type 2 diabetes mellitus: A 3-year longitudinal cohort study.
Moh AMC, Pek SLT, Liu J, Wang J, Subramaniam T, Ang K, Sum CF, Kwan PY, Lee SBM, Tang WE, Lim SC. Moh AMC, et al. Diabetes Res Clin Pract. 2020 Mar;161:107992. doi: 10.1016/j.diabres.2019.107992. Epub 2020 Feb 4. Diabetes Res Clin Pract. 2020. PMID: 32032675
Biomarkers for predicting susceptibility to glycaemic worsening are lacking. This 3-year prospective analysis assessed the utility of several circulating diabetes-related biomarkers for predicting loss of glycaemic control, and their contribution to albuminuria progression …
Biomarkers for predicting susceptibility to glycaemic worsening are lacking. This 3-year prospective analysis assessed the utility of …
Intra-individual variability of eGFR trajectories in early diabetic kidney disease and lack of performance of prognostic biomarkers.
Kerschbaum J, Rudnicki M, Dzien A, Dzien-Bischinger C, Winner H, Heerspink HL, Rosivall L, Wiecek A, Mark PB, Eder S, Denicolò S, Mayer G. Kerschbaum J, et al. Sci Rep. 2020 Nov 12;10(1):19743. doi: 10.1038/s41598-020-76773-0. Sci Rep. 2020. PMID: 33184434 Free PMC article.
Individuals with a detrimental prognosis were identified using various thresholds of a percentage or absolute decline of eGFR after each year of follow up. Next, we determined how many of the patients met the same criteria at other points in time. ...For example, of all su …
Individuals with a detrimental prognosis were identified using various thresholds of a percentage or absolute decline of eGFR after each …
Hyperfiltration in Indigenous Australians with and without diabetes.
Ekinci EI, Hughes JT, Chatfield MD, Lawton PD, Jones GR, Ellis AG, Cass A, Thomas M, MacIsaac RJ, O'Dea K, Jerums G, Maple-Brown LJ. Ekinci EI, et al. Nephrol Dial Transplant. 2015 Nov;30(11):1877-84. doi: 10.1093/ndt/gfv230. Epub 2015 Jul 3. Nephrol Dial Transplant. 2015. PMID: 26142395
HF was defined in various ways: (i) mGFR > 144 mL/min/1.73 m(2), which is mGFR > 1.96 SD above the mean of the mGFR in non-diabetic participants with normal albuminuria and normal renal function (mGFR > 90 mL/min/1.73 m(2)); (ii) age-corrected mGFR (>144 mL/min/1.73 m …
HF was defined in various ways: (i) mGFR > 144 mL/min/1.73 m(2), which is mGFR > 1.96 SD above the mean of the mGFR in non-diabetic pa …
Application of urinary proteomics as possible risk predictor of renal and cardiovascular complications in patients with type 2-diabetes and microalbuminuria.
Oellgaard J, Gæde P, Persson F, Rossing P, Parving HH, Pedersen O. Oellgaard J, et al. J Diabetes Complications. 2018 Dec;32(12):1133-1140. doi: 10.1016/j.jdiacomp.2018.09.012. Epub 2018 Sep 24. J Diabetes Complications. 2018. PMID: 30282584 Clinical Trial.
METHODS: The study was a post hoc analysis of the randomized controlled Steno-2 trial comparing intensified multifactorial intervention to conventional treatment of type 2-diabetes and microalbuminuria. 151 diabetic patients with persistent microalbuminuria were included in ye
METHODS: The study was a post hoc analysis of the randomized controlled Steno-2 trial comparing intensified multifactorial intervention to c …
Can a semi-quantitative method replace the current quantitative method for the annual screening of microalbuminuria in patients with diabetes? Diagnostic accuracy and cost-saving analysis considering the potential health burden.
Kim Y, Park S, Kim MH, Song SH, Lee WM, Kim HS, Jin K, Han S, Kim YC, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK. Kim Y, et al. PLoS One. 2020 Jan 21;15(1):e0227694. doi: 10.1371/journal.pone.0227694. eCollection 2020. PLoS One. 2020. PMID: 31961894 Free PMC article.
OBJECTIVES: Diabetes is a global epidemic, and the high cost of annually and quantitatively measuring urine albumin excretion using the turbidimetric immunoassay is challenging. ...The costs of false results in the semi-quantitative method were calculated based on the a
OBJECTIVES: Diabetes is a global epidemic, and the high cost of annually and quantitatively measuring urine albumin excretion using t …
Arteriolar Hyalinosis Predicts Increase in Albuminuria and GFR Decline in Normo- and Microalbuminuric Japanese Patients With Type 2 Diabetes.
Moriya T, Omura K, Matsubara M, Yoshida Y, Hayama K, Ouchi M. Moriya T, et al. Diabetes Care. 2017 Oct;40(10):1373-1378. doi: 10.2337/dc17-0209. Epub 2017 Aug 3. Diabetes Care. 2017. PMID: 28774945
Glomerular structural changes including mesangial volume fraction [Vv(Mes/glom)] were estimated using EM, whereas the index of arteriolar hyalinosis (IAH) score was assessed by LM. Patients underwent annual measurement of GFR using iohexol injection with simultaneous urine …
Glomerular structural changes including mesangial volume fraction [Vv(Mes/glom)] were estimated using EM, whereas the index of arteriolar hy …
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