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Analytical and biological methods for probing the blood-brain barrier.

Kuhnline Sloan CD, Nandi P, Linz TH, Aldrich JV, Audus KL, Lunte SM. Kuhnline Sloan CD, et al. Among authors: aldrich jv. Annu Rev Anal Chem (Palo Alto Calif). 2012;5:505-31. doi: 10.1146/annurev-anchem-062011-143002. Annu Rev Anal Chem (Palo Alto Calif). 2012. PMID: 22708905 Free PMC article. Review.

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Pathobiology of dynorphins in trauma and disease.

Hauser KF, Aldrich JV, Anderson KJ, Bakalkin G, Christie MJ, Hall ED, Knapp PE, Scheff SW, Singh IN, Vissel B, Woods AS, Yakovleva T, Shippenberg TS. Hauser KF, et al. Among authors: aldrich jv. Front Biosci. 2005 Jan 1;10:216-35. doi: 10.2741/1522. Print 2005 Jan 1. Front Biosci. 2005. PMID: 15574363 Free PMC article. Review.

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Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay.

Zhao Y, Joshi AA, Aldrich JV, Murray TF. Zhao Y, et al. Among authors: aldrich jv. Biomed Pharmacother. 2021 Nov;143:112173. doi: 10.1016/j.biopha.2021.112173. Epub 2021 Sep 15. Biomed Pharmacother. 2021. PMID: 34536757 Free PMC article.

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Peptide kappa opioid receptor ligands: potential for drug development.

Aldrich JV, McLaughlin JP. Aldrich JV, et al. AAPS J. 2009 Jun;11(2):312-22. doi: 10.1208/s12248-009-9105-4. Epub 2009 May 9. AAPS J. 2009. PMID: 19430912 Free PMC article. Review.

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Conformational Constraint between Aromatic Residue Side Chains in the "Message" Sequence of the Peptide Arodyn Using Ring Closing Metathesis Results in a Potent and Selective Kappa Opioid Receptor Antagonist.

Gisemba SA, Ferracane MJ, Murray TF, Aldrich JV. Gisemba SA, et al. Among authors: aldrich jv. J Med Chem. 2021 Mar 25;64(6):3153-3164. doi: 10.1021/acs.jmedchem.0c01984. Epub 2021 Mar 10. J Med Chem. 2021. PMID: 33688737

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Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles.

Brice-Tutt AC, Senadheera SN, Ganno ML, Eans SO, Khaliq T, Murray TF, McLaughlin JP, Aldrich JV. Brice-Tutt AC, et al. Among authors: aldrich jv. Molecules. 2020 Sep 2;25(17):3999. doi: 10.3390/molecules25173999. Molecules. 2020. PMID: 32887303 Free PMC article.

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Alanine scan of the opioid peptide dynorphin B amide.

Joshi AA, Murray TF, Aldrich JV. Joshi AA, et al. Among authors: aldrich jv. Biopolymers. 2017 Sep;108(5):10.1002/bip.23026. doi: 10.1002/bip.23026. Biopolymers. 2017. PMID: 28464209 Free PMC article.

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Opioid Peptides: Potential for Drug Development.

Aldrich JV, McLaughlin JP. Aldrich JV, et al. Drug Discov Today Technol. 2012;9(1):e23-e31. doi: 10.1016/j.ddtec.2011.07.007. Drug Discov Today Technol. 2012. PMID: 23316256 Free PMC article.

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Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour.

Brice-Tutt AC, Wilson LL, Eans SO, Stacy HM, Simons CA, Simpson GG, Coleman JS, Ferracane MJ, Aldrich JV, McLaughlin JP. Brice-Tutt AC, et al. Among authors: aldrich jv. Br J Pharmacol. 2020 Sep;177(18):4209-4222. doi: 10.1111/bph.15165. Epub 2020 Jul 16. Br J Pharmacol. 2020. PMID: 32562259 Free PMC article.

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Design, Synthesis, and Characterization of the Macrocyclic Tetrapeptide cyclo[Pro-Sar-Phe-d-Phe]: A Mixed Opioid Receptor Agonist-Antagonist Following Oral Administration.

Ferracane MJ, Brice-Tutt AC, Coleman JS, Simpson GG, Wilson LL, Eans SO, Stacy HM, Murray TF, McLaughlin JP, Aldrich JV. Ferracane MJ, et al. Among authors: aldrich jv. ACS Chem Neurosci. 2020 May 6;11(9):1324-1336. doi: 10.1021/acschemneuro.0c00086. Epub 2020 Apr 21. ACS Chem Neurosci. 2020. PMID: 32251585

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