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The nuts and bolts of AGC protein kinases.
Pearce LR, Komander D, Alessi DR. Pearce LR, et al. Among authors: alessi dr. Nat Rev Mol Cell Biol. 2010 Jan;11(1):9-22. doi: 10.1038/nrm2822. Nat Rev Mol Cell Biol. 2010. PMID: 20027184 Review.
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. Alessi DR, et al. J Biol Chem. 1995 Nov 17;270(46):27489-94. doi: 10.1074/jbc.270.46.27489. J Biol Chem. 1995. PMID: 7499206
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. Cross DA, et al. Among authors: alessi dr. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):21-6. doi: 10.1042/bj3030021. Biochem J. 1994. PMID: 7945242 Free PMC article.
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S. Alessi DR, et al. EMBO J. 1994 Apr 1;13(7):1610-9. EMBO J. 1994. PMID: 8157000 Free PMC article.
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Alessi DR, Cohen P, Ashworth A, Cowley S, Leevers SJ, Marshall CJ. Alessi DR, et al. Methods Enzymol. 1995;255:279-90. doi: 10.1016/s0076-6879(95)55031-3. Methods Enzymol. 1995. PMID: 8524112 No abstract available.
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Cross DA, et al. Among authors: alessi dr. Nature. 1995 Dec 21-28;378(6559):785-9. doi: 10.1038/378785a0. Nature. 1995. PMID: 8524413
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation.
James SR, Downes CP, Gigg R, Grove SJ, Holmes AB, Alessi DR. James SR, et al. Among authors: alessi dr. Biochem J. 1996 May 1;315 ( Pt 3)(Pt 3):709-13. doi: 10.1042/bj3150709. Biochem J. 1996. PMID: 8645147 Free PMC article.
Mechanism of activation of protein kinase B by insulin and IGF-1.
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Alessi DR, et al. EMBO J. 1996 Dec 2;15(23):6541-51. EMBO J. 1996. PMID: 8978681 Free PMC article.
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P. Alessi DR, et al. FEBS Lett. 1996 Dec 16;399(3):333-8. doi: 10.1016/s0014-5793(96)01370-1. FEBS Lett. 1996. PMID: 8985174
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