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Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Shaw M, Cohen P, Alessi DR. Shaw M, et al. Among authors: alessi dr. FEBS Lett. 1997 Oct 27;416(3):307-11. doi: 10.1016/s0014-5793(97)01235-0. FEBS Lett. 1997. PMID: 9373175
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P. Cross DA, et al. Among authors: alessi dr. Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):21-6. doi: 10.1042/bj3030021. Biochem J. 1994. PMID: 7945242 Free PMC article.
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.
Chen YH, Chen MX, Alessi DR, Campbell DG, Shanahan C, Cohen P, Cohen PT. Chen YH, et al. Among authors: alessi dr. FEBS Lett. 1994 Dec 12;356(1):51-5. doi: 10.1016/0014-5793(94)01231-8. FEBS Lett. 1994. PMID: 7988720
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S. Alessi DR, et al. EMBO J. 1994 Apr 1;13(7):1610-9. EMBO J. 1994. PMID: 8157000 Free PMC article.
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.
Alessi DR, Street AJ, Cohen P, Cohen PT. Alessi DR, et al. Eur J Biochem. 1993 May 1;213(3):1055-66. doi: 10.1111/j.1432-1033.1993.tb17853.x. Eur J Biochem. 1993. PMID: 8389292
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Alessi DR, Cohen P, Ashworth A, Cowley S, Leevers SJ, Marshall CJ. Alessi DR, et al. Methods Enzymol. 1995;255:279-90. doi: 10.1016/s0076-6879(95)55031-3. Methods Enzymol. 1995. PMID: 8524112 No abstract available.
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Cross DA, et al. Among authors: alessi dr. Nature. 1995 Dec 21-28;378(6559):785-9. doi: 10.1038/378785a0. Nature. 1995. PMID: 8524413
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