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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1987 2
1990 2
1992 1
1993 2
1994 1
1995 1
1997 1
1998 1
1999 1
2000 5
2001 5
2002 2
2003 2
2004 9
2005 5
2006 2
2007 7
2008 4
2009 3
2010 8
2011 6
2012 11
2013 10
2014 6
2015 15
2016 14
2017 20
2018 14
2019 14
2020 18
2021 17
2022 10
2023 19
2024 11

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218 results

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Page 1
Metformin: Mechanisms in Human Obesity and Weight Loss.
Yerevanian A, Soukas AA. Yerevanian A, et al. Curr Obes Rep. 2019 Jun;8(2):156-164. doi: 10.1007/s13679-019-00335-3. Curr Obes Rep. 2019. PMID: 30874963 Free PMC article. Review.
The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity. RECENT FINDINGS: Metformin is a first-line therapy for type 2 diabetes. Large cohort studies have shown weight loss benefits associated with metformin therapy. ...
The purpose of this manuscript is to review the mechanisms that underlie metformin's effects on obesity. RECENT FINDINGS: Metformin is a fir …
AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy.
Falk RH, Alexander KM, Liao R, Dorbala S. Falk RH, et al. J Am Coll Cardiol. 2016 Sep 20;68(12):1323-41. doi: 10.1016/j.jacc.2016.06.053. J Am Coll Cardiol. 2016. PMID: 27634125 Free article. Review.
The deposits are derived from 1 of several amyloidogenic precursor proteins, and the prognosis of the disease is determined both by the organ(s) involved and the type of amyloid. Amyloid involvement of the heart (cardiac amyloidosis) carries the worst prognosis of a …
The deposits are derived from 1 of several amyloidogenic precursor proteins, and the prognosis of the disease is determined both by t …
Fibroblasts as immune regulators in infection, inflammation and cancer.
Davidson S, Coles M, Thomas T, Kollias G, Ludewig B, Turley S, Brenner M, Buckley CD. Davidson S, et al. Nat Rev Immunol. 2021 Nov;21(11):704-717. doi: 10.1038/s41577-021-00540-z. Epub 2021 Apr 28. Nat Rev Immunol. 2021. PMID: 33911232 Review.
In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in regulating activation or suppression of an immune response. Fibroblasts are heterogeneous cell …
In chronic infection, inflammation and cancer, the tissue microenvironment controls how local immune cells behave, with tissue-resident fibr …
Dominant Stickler Syndrome.
Soh Z, Richards AJ, McNinch A, Alexander P, Martin H, Snead MP. Soh Z, et al. Genes (Basel). 2022 Jun 18;13(6):1089. doi: 10.3390/genes13061089. Genes (Basel). 2022. PMID: 35741851 Free PMC article. Review.
This review article focuses on the molecular genetics of the autosomal dominant forms of the disease. Pathogenic variants in COL2A1 causing Stickler syndrome usually result in haploinsufficiency of the protein, whereas pathogenic variants of type XI collagen more us …
This review article focuses on the molecular genetics of the autosomal dominant forms of the disease. Pathogenic variants in COL2A1 c …
The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients.
Desmoid Tumor Working Group. Desmoid Tumor Working Group. Eur J Cancer. 2020 Mar;127:96-107. doi: 10.1016/j.ejca.2019.11.013. Epub 2020 Jan 28. Eur J Cancer. 2020. PMID: 32004793 Free article. Review.
Desmoid tumor (DT; other synonymously used terms: Desmoid-type fibromatosis, aggressive fibromatosis) is a rare and locally aggressive monoclonal, fibroblastic proliferation characterised by a variable and often unpredictable clinical course. ...We present herein an eviden …
Desmoid tumor (DT; other synonymously used terms: Desmoid-type fibromatosis, aggressive fibromatosis) is a rare and locally aggressiv …
Role of the IL23/IL17 Pathway in Crohn's Disease.
Schmitt H, Neurath MF, Atreya R. Schmitt H, et al. Front Immunol. 2021 Mar 30;12:622934. doi: 10.3389/fimmu.2021.622934. eCollection 2021. Front Immunol. 2021. PMID: 33859636 Free PMC article. Review.
Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and represents one of the main entities of inflammatory bowel disease (IBD). ...The following review focuses on mechanisms, pathways and specific therapies in Crohn's disease u …
Crohn's disease (CD) is a chronic relapsing disorder of the gastrointestinal tract and represents one of the main entities of inflamm …
A guide to understanding endoplasmic reticulum stress in metabolic disorders.
Lemmer IL, Willemsen N, Hilal N, Bartelt A. Lemmer IL, et al. Mol Metab. 2021 May;47:101169. doi: 10.1016/j.molmet.2021.101169. Epub 2021 Jan 20. Mol Metab. 2021. PMID: 33484951 Free PMC article. Review.
BACKGROUND: The global rise of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease, demands a thorough molecular understanding of the cellular mechanisms that govern health or disease. ...MAJOR CONCLUSIONS: In mammalian biology, …
BACKGROUND: The global rise of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease, demands a th …
Reelin through the years: From brain development to inflammation.
Alexander A, Herz J, Calvier L. Alexander A, et al. Cell Rep. 2023 Jun 27;42(6):112669. doi: 10.1016/j.celrep.2023.112669. Epub 2023 Jun 19. Cell Rep. 2023. PMID: 37339050 Free PMC article. Review.
It is a pro-inflammatory and pro-thrombotic factor with important implications for autoinflammatory and autoimmune diseases such as multiple sclerosis, Alzheimer's disease, arthritis, atherosclerosis, or cancer. Mechanistically, Reelin is a large secreted glycoprotein that …
It is a pro-inflammatory and pro-thrombotic factor with important implications for autoinflammatory and autoimmune diseases such as multiple …
Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report.
Eckardt KU, Alper SL, Antignac C, Bleyer AJ, Chauveau D, Dahan K, Deltas C, Hosking A, Kmoch S, Rampoldi L, Wiesener M, Wolf MT, Devuyst O; Kidney Disease: Improving Global Outcomes. Eckardt KU, et al. Kidney Int. 2015 Oct;88(4):676-83. doi: 10.1038/ki.2015.28. Epub 2015 Mar 4. Kidney Int. 2015. PMID: 25738250 Free article.
Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Juvenile Hyperuricemic Nephropathy (FJHN)', or 'Uromodulin-Associated Kidney Disease (UAKD)' for UMOD-related diseases and 'MCKD typ
Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju …
Type I Alexander disease: Update and validation of the clinical evolution-based classification.
Vaia Y, Mura E, Tonduti D. Vaia Y, et al. Mol Genet Metab. 2023 Mar;138(3):107540. doi: 10.1016/j.ymgme.2023.107540. Epub 2023 Feb 10. Mol Genet Metab. 2023. PMID: 36804850 Review.
BACKGROUND AND OBJECTIVES: Alexander disease (AxD) is a rare progressive leukodystrophy caused by autosomal dominant mutations in the Glial Fibrillary Acidic Protein (GFAP) gene. ...Among these, we identified 65 patients, of whom we had enough information about the …
BACKGROUND AND OBJECTIVES: Alexander disease (AxD) is a rare progressive leukodystrophy caused by autosomal dominant mutations …
218 results