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Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.
Gao Y, Kuwabara H, Spivak CE, Xiao Y, Kellar K, Ravert HT, Kumar A, Alexander M, Hilton J, Wong DF, Dannals RF, Horti AG. Gao Y, et al. Among authors: alexander m. J Med Chem. 2008 Aug 14;51(15):4751-64. doi: 10.1021/jm800323d. Epub 2008 Jul 8. J Med Chem. 2008. PMID: 18605717
Derivatives of (-)-7-methyl-2-(5-(pyridinyl)pyridin-3-yl)-7-azabicyclo[2.2.1]heptane are potential ligands for positron emission tomography imaging of extrathalamic nicotinic acetylcholine receptors.
Gao Y, Horti AG, Kuwabara H, Ravert HT, Hilton J, Holt DP, Kumar A, Alexander M, Endres CJ, Wong DF, Dannals RF. Gao Y, et al. Among authors: alexander m. J Med Chem. 2007 Aug 9;50(16):3814-24. doi: 10.1021/jm070224t. Epub 2007 Jul 13. J Med Chem. 2007. PMID: 17629263
New synthesis and evaluation of enantiomers of 7-methyl-2-exo-(3'-iodo-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane as stereoselective ligands for PET imaging of nicotinic acetylcholine receptors.
Gao Y, Horti AG, Kuwabara H, Ravert HT, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF. Gao Y, et al. Among authors: alexander m. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6168-70. doi: 10.1016/j.bmcl.2008.10.012. Epub 2008 Oct 7. Bioorg Med Chem Lett. 2008. PMID: 18930397
Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.
Gao Y, Ravert HT, Kuwabara H, Xiao Y, Endres CJ, Hilton J, Holt DP, Kumar A, Alexander M, Wong DF, Dannals RF, Horti AG. Gao Y, et al. Among authors: alexander m. Bioorg Med Chem. 2009 Jul 1;17(13):4367-77. doi: 10.1016/j.bmc.2009.05.021. Epub 2009 May 15. Bioorg Med Chem. 2009. PMID: 19481945 Free PMC article.
Sex differences in striatal dopamine release in healthy adults.
Munro CA, McCaul ME, Wong DF, Oswald LM, Zhou Y, Brasic J, Kuwabara H, Kumar A, Alexander M, Ye W, Wand GS. Munro CA, et al. Among authors: alexander m. Biol Psychiatry. 2006 May 15;59(10):966-74. doi: 10.1016/j.biopsych.2006.01.008. Epub 2006 Apr 17. Biol Psychiatry. 2006. PMID: 16616726 Clinical Trial.
Striatal dopamine release and family history of alcoholism.
Munro CA, McCaul ME, Oswald LM, Wong DF, Zhou Y, Brasic J, Kuwabara H, Kumar A, Alexander M, Ye W, Wand GS. Munro CA, et al. Among authors: alexander m. Alcohol Clin Exp Res. 2006 Jul;30(7):1143-51. doi: 10.1111/j.1530-0277.2006.00130.x. Alcohol Clin Exp Res. 2006. PMID: 16792561
3,496 results