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Autosomal dominant Marfan-like connective-tissue disorder with aortic dilation and skeletal anomalies not linked to the fibrillin genes.
Boileau C, Jondeau G, Babron MC, Coulon M, Alexandre JA, Sakai L, Melki J, Delorme G, Dubourg O, Bonaïti-Pellié C, et al. Boileau C, et al. Among authors: alexandre ja. Am J Hum Genet. 1993 Jul;53(1):46-54. Am J Hum Genet. 1993. PMID: 8317497 Free PMC article.
The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.
Firmin FF, Oger F, Gheeraert C, Dubois-Chevalier J, Vercoutter-Edouart AS, Alzaid F, Mazuy C, Dehondt H, Alexandre J, Derudas B, Dhalluin Q, Ploton M, Berthier A, Woitrain E, Lefebvre T, Venteclef N, Pattou F, Staels B, Eeckhoute J, Lefebvre P. Firmin FF, et al. Sci Rep. 2017 Oct 26;7(1):14087. doi: 10.1038/s41598-017-14570-y. Sci Rep. 2017. PMID: 29075020 Free PMC article. Clinical Trial.
Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR).
Berrabah W, Aumercier P, Gheeraert C, Dehondt H, Bouchaert E, Alexandre J, Ploton M, Mazuy C, Caron S, Tailleux A, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P. Berrabah W, et al. Hepatology. 2014 May;59(5):2022-33. doi: 10.1002/hep.26710. Epub 2014 Mar 24. Hepatology. 2014. PMID: 24037988
Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients.
Margerie D, Lefebvre P, Raverdy V, Schwahn U, Ruetten H, Larsen P, Duhamel A, Labreuche J, Thuillier D, Derudas B, Gheeraert C, Dehondt H, Dhalluin Q, Alexandre J, Caiazzo R, Nesslany P, Verkindt H, Pattou F, Staels B. Margerie D, et al. BMC Med Genomics. 2019 Jun 3;12(1):80. doi: 10.1186/s12920-019-0536-1. BMC Med Genomics. 2019. PMID: 31159817 Free PMC article. Clinical Trial.
The hepatic orosomucoid/α1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR.
Porez G, Gross B, Prawitt J, Gheeraert C, Berrabah W, Alexandre J, Staels B, Lefebvre P. Porez G, et al. Endocrinology. 2013 Oct;154(10):3690-701. doi: 10.1210/en.2013-1263. Epub 2013 Jul 16. Endocrinology. 2013. PMID: 23861371
Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex.
Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Maréchal X, Dubois-Chevalier J, Hovasse A, Schaeffer-Reiss C, Cianférani S, Rolando C, Bray F, Duez H, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P. Berthier A, et al. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11033-E11042. doi: 10.1073/pnas.1805397115. Epub 2018 Nov 5. Proc Natl Acad Sci U S A. 2018. PMID: 30397120 Free PMC article.
Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.
Lien F, Berthier A, Bouchaert E, Gheeraert C, Alexandre J, Porez G, Prawitt J, Dehondt H, Ploton M, Colin S, Lucas A, Patrice A, Pattou F, Diemer H, Van Dorsselaer A, Rachez C, Kamilic J, Groen AK, Staels B, Lefebvre P. Lien F, et al. J Clin Invest. 2014 Mar;124(3):1037-51. doi: 10.1172/JCI68815. Epub 2014 Feb 17. J Clin Invest. 2014. PMID: 24531544 Free PMC article.
New 4-Amino-1,2,3-Triazole Inhibitors of Indoleamine 2,3-Dioxygenase Form a Long-Lived Complex with the Enzyme and Display Exquisite Cellular Potency.
Alexandre JAC, Swan MK, Latchem MJ, Boyall D, Pollard JR, Hughes SW, Westcott J. Alexandre JAC, et al. Chembiochem. 2018 Mar 16;19(6):552-561. doi: 10.1002/cbic.201700560. Epub 2018 Jan 31. Chembiochem. 2018. PMID: 29240291
European Hernia Society classification of parastomal hernias.
Śmietański M, Szczepkowski M, Alexandre JA, Berger D, Bury K, Conze J, Hansson B, Janes A, Miserez M, Mandala V, Montgomery A, Morales Conde S, Muysoms F. Śmietański M, et al. Among authors: alexandre ja. Hernia. 2014 Feb;18(1):1-6. doi: 10.1007/s10029-013-1162-z. Epub 2013 Oct 1. Hernia. 2014. PMID: 24081460 Free PMC article.
5',6'-nucleoside phosphonate analogues architecture: synthesis and comparative evaluation towards metabolic enzymes.
Gallier F, Alexandre JA, El Amri C, Deville-Bonne D, Peyrottes S, Périgaud C. Gallier F, et al. Among authors: alexandre ja. ChemMedChem. 2011 Jun 6;6(6):1094-106. doi: 10.1002/cmdc.201100068. Epub 2011 May 12. ChemMedChem. 2011. PMID: 21567966
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