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A transcriptional switch governs fibroblast activation in heart disease.
Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. Alexanian M, et al. Nature. 2021 Jul;595(7867):438-443. doi: 10.1038/s41586-021-03674-1. Epub 2021 Jun 23. Nature. 2021. PMID: 34163071 Free PMC article.
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.
Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, Gonzales C, Sarre A, Alexanian M, Blow MJ, May D, Johnson R, Dauvillier J, Pennacchio LA, Pedrazzini T. Ounzain S, et al. Among authors: alexanian m. J Mol Cell Cardiol. 2014 Nov;76:55-70. doi: 10.1016/j.yjmcc.2014.08.009. Epub 2014 Aug 19. J Mol Cell Cardiol. 2014. PMID: 25149110 Free PMC article.
A transcribed enhancer dictates mesendoderm specification in pluripotency.
Alexanian M, Maric D, Jenkinson SP, Mina M, Friedman CE, Ting CC, Micheletti R, Plaisance I, Nemir M, Maison D, Kernen J, Pezzuto I, Villeneuve D, Burdet F, Ibberson M, Leib SL, Palpant NJ, Hernandez N, Ounzain S, Pedrazzini T. Alexanian M, et al. Nat Commun. 2017 Nov 27;8(1):1806. doi: 10.1038/s41467-017-01804-w. Nat Commun. 2017. PMID: 29180618 Free PMC article.
The Cardiac Myofibroblast.
Alexanian M, Haldar SM. Alexanian M, et al. Circ Res. 2018 Dec 7;123(12):1258-1260. doi: 10.1161/CIRCRESAHA.118.314185. Circ Res. 2018. PMID: 30566054 Free PMC article. No abstract available.
Epigenetic therapies in heart failure.
Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. Alexanian M, et al. J Mol Cell Cardiol. 2019 May;130:197-204. doi: 10.1016/j.yjmcc.2019.04.012. Epub 2019 Apr 13. J Mol Cell Cardiol. 2019. PMID: 30991033 Free PMC article.
Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation.
Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Stratton MS, et al. Among authors: alexanian m. Circ Res. 2019 Sep 13;125(7):662-677. doi: 10.1161/CIRCRESAHA.119.315125. Epub 2019 Aug 14. Circ Res. 2019. PMID: 31409188 Free PMC article.
BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.
Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. Padmanabhan A, et al. Among authors: alexanian m. Circulation. 2020 Dec 15;142(24):2338-2355. doi: 10.1161/CIRCULATIONAHA.120.047753. Epub 2020 Oct 23. Circulation. 2020. PMID: 33094644 Free PMC article.
Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.
Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam PPL, Smith A, Piper M, Christiaen L, Nguyen Q, Bodén M, Palpant NJ. Shim WJ, et al. Among authors: alexanian m. Cell Syst. 2020 Dec 16;11(6):625-639.e13. doi: 10.1016/j.cels.2020.11.001. Epub 2020 Dec 4. Cell Syst. 2020. PMID: 33278344 Free PMC article.
27 results