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ICI 182,780 penetrates brain and hypothalamic tissue and has functional effects in the brain after systemic dosing.
Alfinito PD, Chen X, Atherton J, Cosmi S, Deecher DC. Alfinito PD, et al. Endocrinology. 2008 Oct;149(10):5219-26. doi: 10.1210/en.2008-0532. Epub 2008 Jul 3. Endocrinology. 2008. PMID: 18599545
Estradiol increases catecholamine levels in the hypothalamus of ovariectomized rats during the dark-phase.
Alfinito PD, Chen X, Mastroeni R, Pawlyk AC, Deecher DC. Alfinito PD, et al. Eur J Pharmacol. 2009 Aug 15;616(1-3):334-9. doi: 10.1016/j.ejphar.2009.06.045. Epub 2009 Jul 2. Eur J Pharmacol. 2009. PMID: 19576879
Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunction.
Cosmi S, Pawlyk AC, Alfinito PD, Roman J, Zhou T, Deecher DC. Cosmi S, et al. Among authors: alfinito pd. J Neurosci Methods. 2009 Apr 15;178(2):270-5. doi: 10.1016/j.jneumeth.2008.12.013. Epub 2008 Dec 24. J Neurosci Methods. 2009. PMID: 19135085
Effect of 17alpha-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture.
Pawlyk AC, Alfinito PD, Deecher DC. Pawlyk AC, et al. Among authors: alfinito pd. Eur J Pharmacol. 2008 Sep 4;591(1-3):315-8. doi: 10.1016/j.ejphar.2008.06.084. Epub 2008 Jun 27. Eur J Pharmacol. 2008. PMID: 18619956
Subchronic 17alpha-ethinyl estradiol differentially affects subtypes of sleep and wakefulness in ovariectomized rats.
Pawlyk AC, Alfinito PD, Johnston GH, Deecher DC. Pawlyk AC, et al. Among authors: alfinito pd. Horm Behav. 2008 Jan;53(1):217-24. doi: 10.1016/j.yhbeh.2007.09.018. Epub 2007 Oct 5. Horm Behav. 2008. PMID: 17976600
The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models.
Maswood N, Cosmi S, Alfinito PD, Leventhal L, Deecher DC. Maswood N, et al. Among authors: alfinito pd. Neuroendocrinology. 2006;84(5):330-8. doi: 10.1159/000098322. Epub 2006 Dec 28. Neuroendocrinology. 2006. PMID: 17192701
Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models.
Deecher DC, Alfinito PD, Leventhal L, Cosmi S, Johnston GH, Merchenthaler I, Winneker R. Deecher DC, et al. Among authors: alfinito pd. Endocrinology. 2007 Mar;148(3):1376-83. doi: 10.1210/en.2006-1163. Epub 2006 Nov 22. Endocrinology. 2007. PMID: 17122073
Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats.
Alfinito PD, Huselton C, Chen X, Deecher DC. Alfinito PD, et al. Brain Res. 2006 Jul 7;1098(1):71-8. doi: 10.1016/j.brainres.2006.04.057. Epub 2006 Jun 9. Brain Res. 2006. PMID: 16764833
Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation.
Pawlyk AC, Cosmi S, Alfinito PD, Maswood N, Deecher DC. Pawlyk AC, et al. Among authors: alfinito pd. Brain Res. 2006 Dec 6;1123(1):135-44. doi: 10.1016/j.brainres.2006.09.050. Epub 2006 Oct 24. Brain Res. 2006. PMID: 17067560
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P. O'Neill DJ, et al. Among authors: alfinito pd. J Med Chem. 2010 Jun 10;53(11):4511-21. doi: 10.1021/jm100053t. J Med Chem. 2010. PMID: 20462211
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