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Development of antibiotic resistance and up-regulation of the antimutator gene pfpI in mutator Pseudomonas aeruginosa due to inactivation of two DNA oxidative repair genes (mutY, mutM).
Mandsberg LF, Maciá MD, Bergmann KR, Christiansen LE, Alhede M, Kirkby N, Høiby N, Oliver A, Ciofu O. Mandsberg LF, et al. FEMS Microbiol Lett. 2011 Nov;324(1):28-37. doi: 10.1111/j.1574-6968.2011.02383.x. Epub 2011 Sep 13. FEMS Microbiol Lett. 2011. PMID: 22092761
Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.
Alhede M, Kragh KN, Qvortrup K, Allesen-Holm M, van Gennip M, Christensen LD, Jensen PØ, Nielsen AK, Parsek M, Wozniak D, Molin S, Tolker-Nielsen T, Høiby N, Givskov M, Bjarnsholt T. Alhede M, et al. PLoS One. 2011;6(11):e27943. doi: 10.1371/journal.pone.0027943. Epub 2011 Nov 21. PLoS One. 2011. PMID: 22132176 Free PMC article.
Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa.
Jakobsen TH, Bragason SK, Phipps RK, Christensen LD, van Gennip M, Alhede M, Skindersoe M, Larsen TO, Høiby N, Bjarnsholt T, Givskov M. Jakobsen TH, et al. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. doi: 10.1128/AEM.05992-11. Epub 2012 Jan 27. Appl Environ Microbiol. 2012. PMID: 22286987 Free PMC article.
Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing.
Jakobsen TH, van Gennip M, Phipps RK, Shanmugham MS, Christensen LD, Alhede M, Skindersoe ME, Rasmussen TB, Friedrich K, Uthe F, Jensen PØ, Moser C, Nielsen KF, Eberl L, Larsen TO, Tanner D, Høiby N, Bjarnsholt T, Givskov M. Jakobsen TH, et al. Antimicrob Agents Chemother. 2012 May;56(5):2314-25. doi: 10.1128/AAC.05919-11. Epub 2012 Feb 6. Antimicrob Agents Chemother. 2012. PMID: 22314537 Free PMC article.
Combination of microscopic techniques reveals a comprehensive visual impression of biofilm structure and composition.
Alhede M, Qvortrup K, Liebrechts R, Høiby N, Givskov M, Bjarnsholt T. Alhede M, et al. FEMS Immunol Med Microbiol. 2012 Jul;65(2):335-42. doi: 10.1111/j.1574-695X.2012.00956.x. Epub 2012 Apr 23. FEMS Immunol Med Microbiol. 2012. PMID: 22429654
Interactions between polymorphonuclear leukocytes and Pseudomonas aeruginosa biofilms on silicone implants in vivo.
van Gennip M, Christensen LD, Alhede M, Qvortrup K, Jensen PØ, Høiby N, Givskov M, Bjarnsholt T. van Gennip M, et al. Infect Immun. 2012 Aug;80(8):2601-7. doi: 10.1128/IAI.06215-11. Epub 2012 May 14. Infect Immun. 2012. PMID: 22585963 Free PMC article.
Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria.
Christensen LD, van Gennip M, Rybtke MT, Wu H, Chiang WC, Alhede M, Høiby N, Nielsen TE, Givskov M, Tolker-Nielsen T. Christensen LD, et al. Infect Immun. 2013 Aug;81(8):2705-13. doi: 10.1128/IAI.00332-13. Epub 2013 May 20. Infect Immun. 2013. PMID: 23690403 Free PMC article.
The in vivo biofilm.
Bjarnsholt T, Alhede M, Alhede M, Eickhardt-Sørensen SR, Moser C, Kühl M, Jensen PØ, Høiby N. Bjarnsholt T, et al. Trends Microbiol. 2013 Sep;21(9):466-74. doi: 10.1016/j.tim.2013.06.002. Epub 2013 Jul 2. Trends Microbiol. 2013. PMID: 23827084 Review.
Complete genome sequence of the cystic fibrosis pathogen Achromobacter xylosoxidans NH44784-1996 complies with important pathogenic phenotypes.
Jakobsen TH, Hansen MA, Jensen PØ, Hansen L, Riber L, Cockburn A, Kolpen M, Rønne Hansen C, Ridderberg W, Eickhardt S, Hansen M, Kerpedjiev P, Alhede M, Qvortrup K, Burmølle M, Moser C, Kühl M, Ciofu O, Givskov M, Sørensen SJ, Høiby N, Bjarnsholt T. Jakobsen TH, et al. PLoS One. 2013 Jul 22;8(7):e68484. doi: 10.1371/journal.pone.0068484. Print 2013. PLoS One. 2013. PMID: 23894309 Free PMC article.
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