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Codon optimality is a major determinant of mRNA stability.
Presnyak V, Alhusaini N, Chen YH, Martin S, Morris N, Kline N, Olson S, Weinberg D, Baker KE, Graveley BR, Coller J. Presnyak V, et al. Among authors: alhusaini n. Cell. 2015 Mar 12;160(6):1111-24. doi: 10.1016/j.cell.2015.02.029. Cell. 2015. PMID: 25768907 Free PMC article.
The Ccr4-Not complex monitors the translating ribosome for codon optimality.
Buschauer R, Matsuo Y, Sugiyama T, Chen YH, Alhusaini N, Sweet T, Ikeuchi K, Cheng J, Matsuki Y, Nobuta R, Gilmozzi A, Berninghausen O, Tesina P, Becker T, Coller J, Inada T, Beckmann R. Buschauer R, et al. Among authors: alhusaini n. Science. 2020 Apr 17;368(6488):eaay6912. doi: 10.1126/science.aay6912. Science. 2020. PMID: 32299921
Acetylation of Cytidine in mRNA Promotes Translation Efficiency.
Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, Hosogane M, Sinclair WR, Nanan KK, Mandler MD, Fox SD, Zengeya TT, Andresson T, Meier JL, Coller J, Oberdoerffer S. Arango D, et al. Among authors: alhusaini n. Cell. 2018 Dec 13;175(7):1872-1886.e24. doi: 10.1016/j.cell.2018.10.030. Epub 2018 Nov 15. Cell. 2018. PMID: 30449621 Free PMC article.
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