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Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.
Augustin HG, Koh GY, Thurston G, Alitalo K. Augustin HG, et al. Nat Rev Mol Cell Biol. 2009 Mar;10(3):165-77. doi: 10.1038/nrm2639. Nat Rev Mol Cell Biol. 2009. PMID: 19234476 Review.
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation.
Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W. Grimm J, et al. J Cell Biol. 2001 Jul 23;154(2):345-54. doi: 10.1083/jcb.200102032. J Cell Biol. 2001. PMID: 11470823 Free PMC article.
Tie receptors: new modulators of angiogenic and lymphangiogenic responses.
Jones N, Iljin K, Dumont DJ, Alitalo K. Jones N, et al. Nat Rev Mol Cell Biol. 2001 Apr;2(4):257-67. doi: 10.1038/35067005. Nat Rev Mol Cell Biol. 2001. PMID: 11283723 Review.
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Bergsten E, Uutela M, Li X, Pietras K, Ostman A, Heldin CH, Alitalo K, Eriksson U. Bergsten E, et al. Nat Cell Biol. 2001 May;3(5):512-6. doi: 10.1038/35074588. Nat Cell Biol. 2001. PMID: 11331881
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.
Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, Palotie A, Dewerchin M, Carmeliet P, Alitalo K. Rajantie I, et al. Mol Cell Biol. 2001 Jul;21(14):4647-55. doi: 10.1128/MCB.21.14.4647-4655.2001. Mol Cell Biol. 2001. PMID: 11416142 Free PMC article.
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K. Mäkinen T, et al. Nat Med. 2001 Feb;7(2):199-205. doi: 10.1038/84651. Nat Med. 2001. PMID: 11175851
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.
Karkkainen MJ, Ferrell RE, Lawrence EC, Kimak MA, Levinson KL, McTigue MA, Alitalo K, Finegold DN. Karkkainen MJ, et al. Nat Genet. 2000 Jun;25(2):153-9. doi: 10.1038/75997. Nat Genet. 2000. PMID: 10835628
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response.
Korpelainen EI, Kärkkäinen M, Gunji Y, Vikkula M, Alitalo K. Korpelainen EI, et al. Oncogene. 1999 Jan 7;18(1):1-8. doi: 10.1038/sj.onc.1202288. Oncogene. 1999. PMID: 9926914
Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF.
Korpelainen EI, Karkkainen MJ, Tenhunen A, Lakso M, Rauvala H, Vierula M, Parvinen M, Alitalo K. Korpelainen EI, et al. J Cell Biol. 1998 Dec 14;143(6):1705-12. doi: 10.1083/jcb.143.6.1705. J Cell Biol. 1998. PMID: 9852161 Free PMC article.
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