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Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells.
Aljada A, Ghanim H, Assian E, Dandona P. Aljada A, et al. Metabolism. 2002 Apr;51(4):487-91. doi: 10.1053/meta.2002.31339. Metabolism. 2002. PMID: 11912559
Because tumor necrosis factor-alpha (TNF-a ) is proinflammatory and may thus inhibit the action of insulin at the endothelial cell level, we have now investigated whether TNF-a affects (1) insulin receptor content; (2) insulin receptor (IR) autophosphorylation induc …
Because tumor necrosis factor-alpha (TNF-a ) is proinflammatory and may thus inhibit the action of insulin at the endothelial cell le …
Inflammation: the link between insulin resistance, obesity and diabetes.
Dandona P, Aljada A, Bandyopadhyay A. Dandona P, et al. Among authors: aljada a. Trends Immunol. 2004 Jan;25(1):4-7. doi: 10.1016/j.it.2003.10.013. Trends Immunol. 2004. PMID: 14698276 Review.
Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations of TNF-alpha and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transdu …
Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations o …
Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction.
Chaudhuri A, Janicke D, Wilson M, Ghanim H, Wilding GE, Aljada A, Dandona P. Chaudhuri A, et al. Among authors: aljada a. Am J Cardiol. 2007 Dec 1;100(11):1614-8. doi: 10.1016/j.amjcard.2007.07.014. Am J Cardiol. 2007. PMID: 18036357 Clinical Trial.
Insulin has a free fatty acid (FFA)-suppressive effect, vascular endothelial growth factor (VEGF)- and matrix metalloproteinase (MMP)-lowering effect, and a potential myocardial-protective effect. ...There was no significant increase in myoglobin at 2 hours in the G …
Insulin has a free fatty acid (FFA)-suppressive effect, vascular endothelial growth factor (VEGF)- and matrix metalloproteinase (MMP) …
Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects.
Aljada A, Friedman J, Ghanim H, Mohanty P, Hofmeyer D, Chaudhuri A, Dandona P. Aljada A, et al. Metabolism. 2006 Sep;55(9):1177-85. doi: 10.1016/j.metabol.2006.04.016. Metabolism. 2006. PMID: 16919536
Because hyperglycemia is a major detrimental factor in the prognosis of acute cardiovascular conditions such as acute myocardial infarction (AMI) and stroke, and because an acute glucose challenge in healthy subjects has been shown to induce oxidative stress in mononuclear …
Because hyperglycemia is a major detrimental factor in the prognosis of acute cardiovascular conditions such as acute myocardial infa …
Circulating mononuclear cells in the obese are in a proinflammatory state.
Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. Ghanim H, et al. Among authors: aljada a. Circulation. 2004 Sep 21;110(12):1564-71. doi: 10.1161/01.CIR.0000142055.53122.FA. Epub 2004 Sep 13. Circulation. 2004. PMID: 15364812
BACKGROUND: In view of the increase in plasma concentrations of proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP) in obesity, we investigated whether peripheral blood mononuclear cells (MNC) from obese subjects a …
BACKGROUND: In view of the increase in plasma concentrations of proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleuk …
Endothelial dysfunction and hypertension in diabetes mellitus.
Dandona P, Chaudhuri A, Aljada A. Dandona P, et al. Among authors: aljada a. Med Clin North Am. 2004 Jul;88(4):911-31, x-xi. doi: 10.1016/j.mcna.2004.04.006. Med Clin North Am. 2004. PMID: 15308385 Review.
Although the net balance between vasoconstriction and vasodilation determines the tone of the blood vessel, the vasodilatory-vasoconstrictive response following a challenge may also be determined by the intrinsic mechanical and biological properties of the vascular smooth …
Although the net balance between vasoconstriction and vasodilation determines the tone of the blood vessel, the vasodilatory-vasoconstrictiv …
Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations.
Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. Aljada A, et al. Am J Clin Nutr. 2004 Jul;80(1):51-7. doi: 10.1093/ajcn/80.1.51. Am J Clin Nutr. 2004. PMID: 15213027
BACKGROUND: Glucose intake has been shown to cause an increase in intranuclear nuclear factor-kappa B and a decrease in inhibitor kappa B that are consistent with a proinflammatory effect. ...
BACKGROUND: Glucose intake has been shown to cause an increase in intranuclear nuclear factor-kappa B and a decrease in inhibitor kap …
Endothelial dysfunction, inflammation and diabetes.
Dandona P, Aljada A, Chaudhuri A, Mohanty P. Dandona P, et al. Among authors: aljada a. Rev Endocr Metab Disord. 2004 Aug;5(3):189-97. doi: 10.1023/B:REMD.0000032407.88070.0a. Rev Endocr Metab Disord. 2004. PMID: 15211090 Review. No abstract available.
Evidence for a potent antiinflammatory effect of rosiglitazone.
Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P. Mohanty P, et al. Among authors: aljada a. J Clin Endocrinol Metab. 2004 Jun;89(6):2728-35. doi: 10.1210/jc.2003-032103. J Clin Endocrinol Metab. 2004. PMID: 15181049 Clinical Trial.
We have recently demonstrated a potent antiinflammatory effect of troglitazone, an agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) and a partial agonist of PPARalpha in both the nondiabetic obese and diabetic obese subjects. We have now inves …
We have recently demonstrated a potent antiinflammatory effect of troglitazone, an agonist of peroxisome proliferator-activated recep …
Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.
Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. Aljada A, et al. Am J Clin Nutr. 2004 Apr;79(4):682-90. doi: 10.1093/ajcn/79.4.682. Am J Clin Nutr. 2004. PMID: 15051615 Clinical Trial.
DESIGN: Nine normal-weight subjects were given a 900-kcal mixed meal, and 8 normal-weight subjects were given 300 mL water after an overnight fast. ...The intake of 300 mL water did not induce a change in any of the above indexes. CONCLUSIONS: These data show that t …
DESIGN: Nine normal-weight subjects were given a 900-kcal mixed meal, and 8 normal-weight subjects were given 300 mL water after an o …
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