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Spacer prioritization in CRISPR-Cas9 immunity is enabled by the leader RNA.
Liao C, Sharma S, Svensson SL, Kibe A, Weinberg Z, Alkhnbashi OS, Bischler T, Backofen R, Caliskan N, Sharma CM, Beisel CL. Liao C, et al. Among authors: alkhnbashi os. Nat Microbiol. 2022 Apr;7(4):530-541. doi: 10.1038/s41564-022-01074-3. Epub 2022 Mar 21. Nat Microbiol. 2022. PMID: 35314780
CRISPRloci: comprehensive and accurate annotation of CRISPR-Cas systems.
Alkhnbashi OS, Mitrofanov A, Bonidia R, Raden M, Tran VD, Eggenhofer F, Shah SA, Öztürk E, Padilha VA, Sanches DS, de Carvalho ACPLF, Backofen R. Alkhnbashi OS, et al. Nucleic Acids Res. 2021 Jul 2;49(W1):W125-W130. doi: 10.1093/nar/gkab456. Nucleic Acids Res. 2021. PMID: 34133710 Free PMC article.
Casboundary: automated definition of integral Cas cassettes.
Padilha VA, Alkhnbashi OS, Tran VD, Shah SA, Carvalho ACPLF, Backofen R. Padilha VA, et al. Among authors: alkhnbashi os. Bioinformatics. 2021 Jun 16;37(10):1352-1359. doi: 10.1093/bioinformatics/btaa984. Bioinformatics. 2021. PMID: 33226067 Free PMC article.
Adaptation induced by self-targeting in a type I-B CRISPR-Cas system.
Stachler AE, Wörtz J, Alkhnbashi OS, Turgeman-Grott I, Smith R, Allers T, Backofen R, Gophna U, Marchfelder A. Stachler AE, et al. Among authors: alkhnbashi os. J Biol Chem. 2020 Sep 25;295(39):13502-13515. doi: 10.1074/jbc.RA120.014030. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723866 Free PMC article.
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV. Makarova KS, et al. Among authors: alkhnbashi os. Nat Rev Microbiol. 2020 Feb;18(2):67-83. doi: 10.1038/s41579-019-0299-x. Epub 2019 Dec 19. Nat Rev Microbiol. 2020. PMID: 31857715 Free PMC article. Review.
24 results