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Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient.
Allan KM, Astore MA, Kardia E, Wong SL, Fawcett LK, Bell JL, Visser S, Chen PC, Griffith R, Jaffe A, Sivam S, Vittorio O, Kuyucak S, Waters SA. Allan KM, et al. Front Mol Biosci. 2023 Jun 1;10:1148501. doi: 10.3389/fmolb.2023.1148501. eCollection 2023. Front Mol Biosci. 2023. PMID: 37325471 Free PMC article.
Molecular Dynamics and Theratyping in Airway and Gut Organoids Reveal R352Q-CFTR Conductance Defect.
Wong SL, Awatade NT, Astore MA, Allan KM, Carnell MJ, Slapetova I, Chen PC, Setiadi J, Pandzic E, Fawcett LK, Widger JR, Whan RM, Griffith R, Ooi CY, Kuyucak S, Jaffe A, Waters SA. Wong SL, et al. Among authors: allan km. Am J Respir Cell Mol Biol. 2022 Jul;67(1):99-111. doi: 10.1165/rcmb.2021-0337OC. Am J Respir Cell Mol Biol. 2022. PMID: 35471184 Free PMC article.
Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity.
Wong SL, Awatade NT, Astore MA, Allan KM, Carnell MJ, Slapetova I, Chen PC, Capraro A, Fawcett LK, Whan RM, Griffith R, Ooi CY, Kuyucak S, Jaffe A, Waters SA. Wong SL, et al. Among authors: allan km. iScience. 2021 Dec 31;25(1):103710. doi: 10.1016/j.isci.2021.103710. eCollection 2022 Jan 21. iScience. 2021. PMID: 35072004 Free PMC article.
Concise total syntheses of (-)-jorunnamycin A and (-)-jorumycin enabled by asymmetric catalysis.
Welin ER, Ngamnithiporn A, Klatte M, Lapointe G, Pototschnig GM, McDermott MSJ, Conklin D, Gilmore CD, Tadross PM, Haley CK, Negoro K, Glibstrup E, Grünanger CU, Allan KM, Virgil SC, Slamon DJ, Stoltz BM. Welin ER, et al. Among authors: allan km. Science. 2019 Jan 18;363(6424):270-275. doi: 10.1126/science.aav3421. Epub 2018 Dec 20. Science. 2019. PMID: 30573544 Free PMC article.
32 results