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CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Alexander RP, Warrellow GJ, Eaton MA, Boyd EC, Head JC, Porter JR, Brown JA, Reuberson JT, Hutchinson B, Turner P, Boyce B, Barnes D, Mason B, Cannell A, Taylor RJ, Zomaya A, Millican A, Leonard J, Morphy R, Wales M, Perry M, Allen RA, Gozzard N, Hughes B, Higgs G. Alexander RP, et al. Among authors: allen ra. Bioorg Med Chem Lett. 2002 Jun 3;12(11):1451-6. doi: 10.1016/s0960-894x(02)00202-0. Bioorg Med Chem Lett. 2002. PMID: 12031318
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Hughes B, Howat D, Lisle H, Holbrook M, James T, Gozzard N, Blease K, Hughes P, Kingaby R, Warrellow G, Alexander R, Head J, Boyd E, Eaton M, Perry M, Wales M, Smith B, Owens R, Catterall C, Lumb S, Russell A, Allen R, Merriman M, Bloxham D, Higgs G. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91. doi: 10.1111/j.1476-5381.1996.tb15522.x. Br J Pharmacol. 1996. PMID: 8818342 Free PMC article.
CDP840: a novel inhibitor of PDE-4.
Perry MJ, O'Connell J, Walker C, Crabbe T, Baldock D, Russell A, Lumb S, Huang Z, Howat D, Allen R, Merriman M, Walls J, Daniel T, Hughes B, Laliberte F, Higgs GA, Owens RJ. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32. doi: 10.1007/BF02737831. Cell Biochem Biophys. 1998. PMID: 9631241
Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3Kδ.
Allen RA, Brookings DC, Powell MJ, Delgado J, Shuttleworth LK, Merriman M, Fahy IJ, Tewari R, Silva JP, Healy LJ, Davies GCG, Twomey B, Cutler RM, Kotian A, Crosby A, McCluskey G, Watt GF, Payne A. Allen RA, et al. J Pharmacol Exp Ther. 2017 Jun;361(3):429-440. doi: 10.1124/jpet.116.237347. Epub 2017 Apr 25. J Pharmacol Exp Ther. 2017. PMID: 28442583
Fused thiophene derivatives as MEK inhibitors.
Laing VE, Brookings DC, Carbery RJ, Simorte JG, Hutchings MC, Langham BJ, Lowe MA, Allen RA, Fetterman JR, Turner J, Meier C, Kennedy J, Merriman M. Laing VE, et al. Among authors: allen ra. Bioorg Med Chem Lett. 2012 Jan 1;22(1):472-5. doi: 10.1016/j.bmcl.2011.10.105. Epub 2011 Nov 6. Bioorg Med Chem Lett. 2012. PMID: 22119475
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