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Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.
Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA. Kraakman MJ, et al. Among authors: allen tl. Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Cell Metab. 2015. PMID: 25738456 Free article.
Targeting gp130 to prevent inflammation and promote insulin action.
Kraakman MJ, Allen TL, Whitham M, Iliades P, Kammoun HL, Estevez E, Lancaster GI, Febbraio MA. Kraakman MJ, et al. Among authors: allen tl. Diabetes Obes Metab. 2013 Sep;15 Suppl 3:170-5. doi: 10.1111/dom.12170. Diabetes Obes Metab. 2013. PMID: 24003934 Review.
Genetic manipulation of cardiac Hsp72 levels does not alter substrate metabolism but reveals insights into high-fat feeding-induced cardiac insulin resistance.
Henstridge DC, Estevez E, Allen TL, Heywood SE, Gardner T, Yang C, Mellett NA, Kingwell BA, Meikle PJ, Febbraio MA. Henstridge DC, et al. Among authors: allen tl. Cell Stress Chaperones. 2015 May;20(3):461-72. doi: 10.1007/s12192-015-0571-6. Epub 2015 Jan 25. Cell Stress Chaperones. 2015. PMID: 25618331 Free PMC article.
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance.
Matthews VB, Allen TL, Risis S, Chan MH, Henstridge DC, Watson N, Zaffino LA, Babb JR, Boon J, Meikle PJ, Jowett JB, Watt MJ, Jansson JO, Bruce CR, Febbraio MA. Matthews VB, et al. Among authors: allen tl. Diabetologia. 2010 Nov;53(11):2431-41. doi: 10.1007/s00125-010-1865-y. Epub 2010 Aug 11. Diabetologia. 2010. PMID: 20697689
Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice.
Henstridge DC, Bruce CR, Pang CP, Lancaster GI, Allen TL, Estevez E, Gardner T, Weir JM, Meikle PJ, Lam KSL, Xu A, Fujii N, Goodyear LJ, Febbraio MA. Henstridge DC, et al. Among authors: allen tl. Diabetologia. 2012 Oct;55(10):2769-2778. doi: 10.1007/s00125-012-2652-8. Epub 2012 Jul 26. Diabetologia. 2012. PMID: 22832498 Free PMC article.
92 results