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Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer.
Clin Cancer Res. 2015 Nov 15;21(22):5121-5130. doi: 10.1158/1078-0432.CCR-15-0360. Epub 2015 May 19.
Clin Cancer Res. 2015.
PMID: 25991817
Free PMC article.
Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
Wardell SE, Nelson ER, Chao CA, Alley HM, McDonnell DP.
Wardell SE, et al. Among authors: alley hm.
Endocr Relat Cancer. 2015 Oct;22(5):713-24. doi: 10.1530/ERC-15-0287. Epub 2015 Jul 10.
Endocr Relat Cancer. 2015.
PMID: 26162914
Free PMC article.
Item in Clipboard
CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.
Stice JP, Wardell SE, Norris JD, Yllanes AP, Alley HM, Haney VO, White HS, Safi R, Winter PS, Cocce KJ, Kishton RJ, Lawrence SA, Strum JC, McDonnell DP.
Stice JP, et al. Among authors: alley hm.
Mol Cancer Res. 2017 Jun;15(6):660-669. doi: 10.1158/1541-7786.MCR-17-0028. Epub 2017 Feb 16.
Mol Cancer Res. 2017.
PMID: 28209757
Free PMC article.
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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.
Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, Anderson GR, Winter PS, Wang T, Alley HM, Kwong LN, Cooper ZA, Tetzlaff M, Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, Wood KC.
Martz CA, et al. Among authors: alley hm.
Sci Signal. 2014 Dec 23;7(357):ra121. doi: 10.1126/scisignal.aaa1877.
Sci Signal. 2014.
PMID: 25538079
Free PMC article.
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Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.
Pollock JA, Wardell SE, Parent AA, Stagg DB, Ellison SJ, Alley HM, Chao CA, Lawrence SA, Stice JP, Spasojevic I, Baker JG, Kim SH, McDonnell DP, Katzenellenbogen JA, Norris JD.
Pollock JA, et al. Among authors: alley hm.
Nat Chem Biol. 2016 Oct;12(10):795-801. doi: 10.1038/nchembio.2131. Epub 2016 Aug 8.
Nat Chem Biol. 2016.
PMID: 27501397
Free PMC article.
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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC.
Anderson GR, et al. Among authors: alley hm.
Sci Transl Med. 2016 Dec 14;8(369):369ra175. doi: 10.1126/scitranslmed.aae0348.
Sci Transl Med. 2016.
PMID: 27974663
Free PMC article.
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Androgen receptor antagonism drives cytochrome P450 17A1 inhibitor efficacy in prostate cancer.
Norris JD, Ellison SJ, Baker JG, Stagg DB, Wardell SE, Park S, Alley HM, Baldi RM, Yllanes A, Andreano KJ, Stice JP, Lawrence SA, Eisner JR, Price DK, Moore WR, Figg WD, McDonnell DP.
Norris JD, et al. Among authors: alley hm.
J Clin Invest. 2017 Jun 1;127(6):2326-2338. doi: 10.1172/JCI87328. Epub 2017 May 2.
J Clin Invest. 2017.
PMID: 28463227
Free PMC article.
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Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer.
McLeod AB, Stice JP, Wardell SE, Alley HM, Chang CY, McDonnell DP.
McLeod AB, et al. Among authors: alley hm.
Prostate. 2018 Mar;78(4):266-277. doi: 10.1002/pros.23467. Epub 2017 Dec 15.
Prostate. 2018.
PMID: 29243324
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