Organocatalytic carbonyl-olefin metathesis

J Am Chem Soc. 2012 Nov 14;134(45):18581-4. doi: 10.1021/ja309650u. Epub 2012 Nov 5.

Abstract

The development of a catalytic carbonyl-olefin metathesis strategy is reported, in the context of the ring-opening metathesis of cyclopropenes with aldehydes using a simple hydrazine catalyst. The key to this reaction is a conceptual blueprint for metathesis chemistry that forgoes the traditional reliance on [2 + 2] cycloaddition modes in favor of a [3 + 2] paradigm.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Cyclopropanes / chemistry*
  • Hydrazines / chemistry*
  • Molecular Structure

Substances

  • Aldehydes
  • Cyclopropanes
  • Hydrazines
  • hydrazine
  • cyclopropene