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Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter.
Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. Eskandari SK, et al. Among authors: allos h. Sci Transl Med. 2020 Nov 11;12(569):eaaw4744. doi: 10.1126/scitranslmed.aaw4744. Sci Transl Med. 2020. PMID: 33177180 Free PMC article.
Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts.
Choi JY, Eskandari SK, Cai S, Sulkaj I, Assaker JP, Allos H, AlHaddad J, Muhsin SA, Alhussain E, Mansouri A, Yeung MY, Seelen MAJ, Kim HJ, Cantor H, Azzi JR. Choi JY, et al. Among authors: allos h. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6042-6046. doi: 10.1073/pnas.1918950117. Epub 2020 Feb 28. Proc Natl Acad Sci U S A. 2020. PMID: 32111690 Free PMC article.
mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis.
Eskandari SK, Allos H, Al Dulaijan BS, Melhem G, Sulkaj I, Alhaddad JB, Saad AJ, Deban C, Chu P, Choi JY, Kollar B, Pomahac B, Riella LV, Berger SP, Sanders JSF, Lieberman J, Li L, Azzi JR. Eskandari SK, et al. Among authors: allos h. Front Immunol. 2022 Jun 10;13:899975. doi: 10.3389/fimmu.2022.899975. eCollection 2022. Front Immunol. 2022. PMID: 35757726 Free PMC article.
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo.
Cai S, Choi JY, Borges TJ, Zhang H, Miao J, Ichimura T, Li X, Xu S, Chu P, Eskandari SK, Allos H, Alhaddad JB, Muhsin SA, Yatim K, Riella LV, Sage PT, Chandraker AK, Azzi JR. Cai S, et al. Among authors: allos h. Sci Rep. 2020 Aug 28;10(1):14249. doi: 10.1038/s41598-020-71289-z. Sci Rep. 2020. PMID: 32859934 Free PMC article.
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection.
El Fekih R, Hurley J, Tadigotla V, Alghamdi A, Srivastava A, Coticchia C, Choi J, Allos H, Yatim K, Alhaddad J, Eskandari S, Chu P, Mihali AB, Lape IT, Lima Filho MP, Aoyama BT, Chandraker A, Safa K, Markmann JF, Riella LV, Formica RN, Skog J, Azzi JR. El Fekih R, et al. Among authors: allos h. J Am Soc Nephrol. 2021 Apr;32(4):994-1004. doi: 10.1681/ASN.2020060850. Epub 2021 Mar 3. J Am Soc Nephrol. 2021. PMID: 33658284 Free PMC article.