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Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation.
Antoniades C, Shirodaria C, Crabtree M, Rinze R, Alp N, Cunnington C, Diesch J, Tousoulis D, Stefanadis C, Leeson P, Ratnatunga C, Pillai R, Channon KM. Antoniades C, et al. Circulation. 2007 Dec 11;116(24):2851-9. doi: 10.1161/CIRCULATIONAHA.107.704155. Epub 2007 Nov 26. Circulation. 2007. PMID: 18040031
Elevated blood pressure in offspring born premature to hypertensive pregnancy: is endothelial dysfunction the underlying vascular mechanism?
Lazdam M, de la Horra A, Pitcher A, Mannie Z, Diesch J, Trevitt C, Kylintireas I, Contractor H, Singhal A, Lucas A, Neubauer S, Kharbanda R, Alp N, Kelly B, Leeson P. Lazdam M, et al. Hypertension. 2010 Jul;56(1):159-65. doi: 10.1161/HYPERTENSIONAHA.110.150235. Epub 2010 May 17. Hypertension. 2010. PMID: 20479334 Clinical Trial.
Severe endothelial dysfunction in the aorta of a mouse model of Fabry disease; partial prevention by N-butyldeoxynojirimycin treatment.
Heare T, Alp NJ, Priestman DA, Kulkarni AB, Qasba P, Butters TD, Dwek RA, Clarke K, Channon KM, Platt FM. Heare T, et al. J Inherit Metab Dis. 2007 Feb;30(1):79-87. doi: 10.1007/s10545-006-0473-y. Epub 2006 Dec 25. J Inherit Metab Dis. 2007. PMID: 17189993
Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure revealed by eNOS-GTP cyclohydrolase 1 double transgenic mice.
Adlam D, Bendall JK, De Bono JP, Alp NJ, Khoo J, Nicoli T, Yokoyama M, Kawashima S, Channon KM. Adlam D, et al. Exp Physiol. 2007 Jan;92(1):119-26. doi: 10.1113/expphysiol.2006.035113. Epub 2006 Sep 28. Exp Physiol. 2007. PMID: 17012144
Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation.
Carnicer R, Hale AB, Suffredini S, Liu X, Reilly S, Zhang MH, Surdo NC, Bendall JK, Crabtree MJ, Lim GB, Alp NJ, Channon KM, Casadei B. Carnicer R, et al. Among authors: alp nj. Circ Res. 2012 Aug 31;111(6):718-27. doi: 10.1161/CIRCRESAHA.112.274464. Epub 2012 Jul 12. Circ Res. 2012. PMID: 22798524
A requirement for Gch1 and tetrahydrobiopterin in embryonic development.
Douglas G, Hale AB, Crabtree MJ, Ryan BJ, Hansler A, Watschinger K, Gross SS, Lygate CA, Alp NJ, Channon KM. Douglas G, et al. Among authors: alp nj. Dev Biol. 2015 Mar 1;399(1):129-138. doi: 10.1016/j.ydbio.2014.12.025. Epub 2014 Dec 31. Dev Biol. 2015. PMID: 25557619 Free PMC article.
Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding.
Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S, Crossman DC. Chamberlain J, et al. PLoS One. 2009;4(4):e5073. doi: 10.1371/journal.pone.0005073. Epub 2009 Apr 6. PLoS One. 2009. PMID: 19347044 Free PMC article.
Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM. Chuaiphichai S, et al. Among authors: alp nj. Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28. Hypertension. 2014. PMID: 24777984 Free PMC article.
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