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1970 3
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1979 44
1980 69
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1994 117
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1998 124
1999 148
2000 161
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2002 133
2003 222
2004 177
2005 164
2006 176
2007 164
2008 133
2009 161
2010 169
2011 155
2012 144
2013 148
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5,427 results

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Page 1
Exploring FDA-Approved Frontiers: Insights into Natural and Engineered Peptide Analogues in the GLP-1, GIP, GHRH, CCK, ACTH, and alpha-MSH Realms.
Al Musaimi O. Al Musaimi O. Biomolecules. 2024 Feb 22;14(3):264. doi: 10.3390/biom14030264. Biomolecules. 2024. PMID: 38540684 Free PMC article. Review.
Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of insulin in 1921, the Food and Drug Administration (FDA) has authorised around 100 peptides for various applications. ...In this review, I analyse the FDA approval of natural …
Peptides continue to gain significance in the pharmaceutical arena. Since the unveiling of insulin in 1921, the Food and Drug Adminis …
Mechanisms of antiinflammatory action of the neuroimmunomodulatory peptide alpha-MSH.
Lipton JM, Catania A. Lipton JM, et al. Ann N Y Acad Sci. 1998 May 1;840:373-80. doi: 10.1111/j.1749-6632.1998.tb09576.x. Ann N Y Acad Sci. 1998. PMID: 9629264 Review.
The antiinflammatory effects of alpha-melanocyte-stimulating hormone (alpha-MSH) molecules, specifically alpha-MSH(1-13) and its COOH-terminal tripeptide alpha-MSH(11-13), are well established. ...The broad effectiveness of alph …
The antiinflammatory effects of alpha-melanocyte-stimulating hormone (alpha-MSH) molecules, specifically alpha- …
Bremelanotide: First Approval.
Dhillon S, Keam SJ. Dhillon S, et al. Drugs. 2019 Sep;79(14):1599-1606. doi: 10.1007/s40265-019-01187-w. Drugs. 2019. PMID: 31429064 Review.
Initially developed by Palatin Technologies who sponsored the Phase 3 clinical trials, bremelanotide was subsequently out-licensed to AMAG Pharmaceuticals Inc. for exclusive North American rights to develop and commercialize the drug, including submitting the New Drug Application …
Initially developed by Palatin Technologies who sponsored the Phase 3 clinical trials, bremelanotide was subsequently out-licensed to AMAG P …
Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of alpha-MSH-Peptide Conjugates.
Szabó I, Biri-Kovács B, Vári B, Ranđelović I, Vári-Mező D, Juhász É, Halmos G, Bősze S, Tóvári J, Mező G. Szabó I, et al. Int J Mol Sci. 2024 Jan 16;25(2):1095. doi: 10.3390/ijms25021095. Int J Mol Sci. 2024. PMID: 38256168 Free PMC article.
Its native ligand, alpha-MSH (alpha-melanocyte-stimulating hormone) peptide, or its derivatives, might be potential homing devices for this purpose. Therefore, we prepared three alpha-MSH derivative-daunomycin (Dau) conjugates and their i …
Its native ligand, alpha-MSH (alpha-melanocyte-stimulating hormone) peptide, or its derivatives, might be potent …
Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues.
Fung S, Hruby VJ. Fung S, et al. Curr Opin Chem Biol. 2005 Aug;9(4):352-8. doi: 10.1016/j.cbpa.2005.06.010. Curr Opin Chem Biol. 2005. PMID: 16023401 Free PMC article. Review.
Its importance has been so well established that modern day schemes for ligand-based drug design often start with cyclization of linear peptides to rigidify peptide structure, to limit its conformational possibilities, and to find key pharmacophore elements in three …
Its importance has been so well established that modern day schemes for ligand-based drug design often start with cyclization of linear p …
alpha-MSH and desacetyl-alpha-MSH signaling through melanocortin receptors.
Mountjoy KG, Wu CS, Cornish J, Callon KE. Mountjoy KG, et al. Ann N Y Acad Sci. 2003 Jun;994:58-65. doi: 10.1111/j.1749-6632.2003.tb03162.x. Ann N Y Acad Sci. 2003. PMID: 12851298 Review.
N-terminal acetylation of ACTH[1-13]NH(2) (known as desacetyl-alpha-MSH) to produce alpha-MSH enhances some activities of ACTH[1-13]NH(2) and virtually eliminates others. To determine whether alpha-MSH and desacetyl-alpha-MSH …
N-terminal acetylation of ACTH[1-13]NH(2) (known as desacetyl-alpha-MSH) to produce alpha-MSH enhances some acti …
Does alpha-MSH have a role in regulating skin pigmentation in humans?
Thody AJ, Graham A. Thody AJ, et al. Pigment Cell Res. 1998 Oct;11(5):265-74. doi: 10.1111/j.1600-0749.1998.tb00735.x. Pigment Cell Res. 1998. PMID: 9877097 Review.
Second, the human pituitary, unlike that of most mammals, secretes very little alpha-MSH and circulatory levels of the peptide in humans are extremely low. However, there is now evidence from several groups that alpha-MSH is capable of stimulati …
Second, the human pituitary, unlike that of most mammals, secretes very little alpha-MSH and circulatory levels of the pept …
A gel-forming alpha-MSH analog promotes lasting melanogenesis.
Chang CL, Cai Z, Hsu SYT. Chang CL, et al. Eur J Pharmacol. 2023 Nov 5;958:176008. doi: 10.1016/j.ejphar.2023.176008. Epub 2023 Sep 4. Eur J Pharmacol. 2023. PMID: 37673364
The alpha-MSH peptide plays a significant role in the regulation of pigmentation via the melanocortin 1 receptor (MC1R). ...Recently, alpha-MSH analogs have been approved for the treatment of erythropoietic protoporphyria, hypoactive sexual desi …
The alpha-MSH peptide plays a significant role in the regulation of pigmentation via the melanocortin 1 receptor (MC1R) …
Antimicrobial properties of alpha-MSH and related synthetic melanocortins.
Catania A, Colombo G, Rossi C, Carlin A, Sordi A, Lonati C, Turcatti F, Leonardi P, Grieco P, Gatti S. Catania A, et al. ScientificWorldJournal. 2006 Oct 2;6:1241-6. doi: 10.1100/tsw.2006.227. ScientificWorldJournal. 2006. PMID: 17028769 Free PMC article. Review.
Several properties of alpha-melanocyte stimulating hormone (alpha-MSH) suggested that it could be a natural antimicrobial peptide. Alpha-MSH is a primordial peptide that appeared during the Paleozoic era, long before adaptive immun …
Several properties of alpha-melanocyte stimulating hormone (alpha-MSH) suggested that it could be a natural antimicrobi …
Alpha-melanocyte stimulating hormone: an emerging anti-inflammatory antimicrobial peptide.
Singh M, Mukhopadhyay K. Singh M, et al. Biomed Res Int. 2014;2014:874610. doi: 10.1155/2014/874610. Epub 2014 Jul 23. Biomed Res Int. 2014. PMID: 25140322 Free PMC article. Review.
Similar to alpha-MSH's anti-inflammatory properties, its C-terminal residues also exhibit antimicrobial activity parallel to that of the entire peptide. This review is focused on the current findings regarding the direct antimicrobial potential and immunomodu …
Similar to alpha-MSH's anti-inflammatory properties, its C-terminal residues also exhibit antimicrobial activity parallel to t …
5,427 results