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alpha-Pyrrolidinohexanophenone (alpha-PHP) and alpha-Pyrrolidinoisohexanophenone (alpha-PiHP): A Review.
Dinis P, Franco J, Margalho C. Dinis P, et al. Life (Basel). 2024 Mar 22;14(4):429. doi: 10.3390/life14040429. Life (Basel). 2024. PMID: 38672701 Free PMC article. Review.
By 2022, 1184 of these substances had been identified over a period of 16 years. Within these, alpha-pyrrolidinohexanophenone (alpha-PHP) and alpha-pyrrolidinoisohexanophenone (alpha-PiHP) have emerged, two synthetic cathinones from the pyrovalerone de …
By 2022, 1184 of these substances had been identified over a period of 16 years. Within these, alpha-pyrrolidinohexanophenone …
Pyrrolidinyl Synthetic Cathinones alpha-PHP and 4F-alpha-PVP Metabolite Profiling Using Human Hepatocyte Incubations.
Carlier J, Diao X, Giorgetti R, Busardò FP, Huestis MA. Carlier J, et al. Int J Mol Sci. 2020 Dec 28;22(1):230. doi: 10.3390/ijms22010230. Int J Mol Sci. 2020. PMID: 33379373 Free PMC article.
Experiments were conducted using pooled human hepatocyte incubations followed by liquid chromatography-high-resolution tandem mass spectrometry and data-mining software. We suggest alpha-PHP dihydroxy-pyrrolidinyl, alpha-PHP hexanol, alpha-PH …
Experiments were conducted using pooled human hepatocyte incubations followed by liquid chromatography-high-resolution tandem mass spectrome …
alpha-PHP: Acute effects and pharmacokinetic in male and female mice, and clinical data on related intoxications.
Bassi M, Roda E, Tirri M, Corli G, Bilel S, Bernardi T, Boccuto F, Borsari M, Buscaglia E, De Luca F, Di Rosa F, Gregori A, Buccilli V, Maida P, Ambrogi D, Strano-Rossi S, Locatelli CA, Marti M. Bassi M, et al. Drug Alcohol Depend. 2025 Apr 1;269:112596. doi: 10.1016/j.drugalcdep.2025.112596. Epub 2025 Feb 15. Drug Alcohol Depend. 2025. PMID: 39987764 Free article.
Alpha-Pyrrolidinohexanophenone (alpha-PHP) is a synthetic pyrovalerone derivative with structural characteristics and stimulant effects on humans comparable to alpha-PVP and MDPV. Since its pharmaco-toxicological effects have been poorly investigated, …
Alpha-Pyrrolidinohexanophenone (alpha-PHP) is a synthetic pyrovalerone derivative with structural characteristic …
alpha-Pyrrolidinohexanophenone (alpha-PHP) vs. alpha-pyrrolidinoisohexanophenone (alpha-PiHP): A toxicological investigation about plasma concentrations and behavior in forensic routine cases.
Brueckner I, Welter-Luedeke J, Zangl A, Graw M, Paul LD. Brueckner I, et al. J Anal Toxicol. 2024 Jun 11;48(5):299-313. doi: 10.1093/jat/bkae011. J Anal Toxicol. 2024. PMID: 38491987
The presented study reports on two members of this substance group, alpha-pyrrolidinohexanophenone (alpha-PHP) and alpha-pyrrolidinoisohexanophenone (alpha-PiHP), which occurred in forensic routine cases in the last 6 years. alpha-PHP cou …
The presented study reports on two members of this substance group, alpha-pyrrolidinohexanophenone (alpha-PHP) a …
Structure-Activity Relationships for a Recently Controlled Synthetic Cathinone Dopamine Transporter Reuptake Inhibitor: alpha-Pyrrolidinohexiophenone (alpha-PHP).
Davies RA, Nguyen VT, Eltit JM, Glennon RA. Davies RA, et al. ACS Chem Neurosci. 2023 Jul 19;14(14):2527-2536. doi: 10.1021/acschemneuro.3c00156. Epub 2023 Jul 5. ACS Chem Neurosci. 2023. PMID: 37406364 Free PMC article.
Schedule I controlled substances. Structurally, alpha-PVP and alpha-PHP possess a common terminal N-pyrrolidine moiety and differ only with respect to the length of their alpha-alkyl chain. Using a synaptosomal assay, we previously reported that alpha-PHP …
Schedule I controlled substances. Structurally, alpha-PVP and alpha-PHP possess a common terminal N-pyrrolidine moiety and dif …
Toxicological Investigation of a Case Series Involving the Synthetic Cathinone alpha-Pyrrolidinohexiophenone (alpha-PHP) and Identification of Phase I and II Metabolites in Human Urine.
Grapp M, Kaufmann C, Schwelm HM, Neukamm MA. Grapp M, et al. J Anal Toxicol. 2023 Mar 21;47(2):162-174. doi: 10.1093/jat/bkac057. J Anal Toxicol. 2023. PMID: 35921233
alpha-Pyrrolidinohexiophenone (alpha-PHP) is a derivative of the class of alpha-pyrrolidinophenones, a subgroup of synthetic cathinones. ...Apart from the parent drug, most abundant findings in urine were the metabolites dihydroxy-pyrrolidinyl-alpha-PHP …
alpha-Pyrrolidinohexiophenone (alpha-PHP) is a derivative of the class of alpha-pyrrolidinophenones, a subgroup of synthetic c …
In vitro metabolic studies and machine learning analysis of mass spectrometry data: A dual strategy for differentiating alpha-pyrrolidinohexiophenone (alpha-PHP) and alpha-pyrrolidinoisohexanophenone (alpha-PiHP) in urine analysis.
Yeh YL, Wen CY, Hsieh CL, Chang YH, Wang SM. Yeh YL, et al. Forensic Sci Int. 2024 Aug;361:112134. doi: 10.1016/j.forsciint.2024.112134. Epub 2024 Jul 6. Forensic Sci Int. 2024. PMID: 38996540
However, the analysis of isomeric NPSs such as alpha-PiHP and alpha-pyrrolidinohexiophenone (alpha-PHP) is challenging owing to similarities in their retention times and mass spectra. ...After 5 h incubation, 71.4 % of alpha-PHP and 64.7 % of alpha-PiH …
However, the analysis of isomeric NPSs such as alpha-PiHP and alpha-pyrrolidinohexiophenone (alpha-PHP) is challenging owing t …
Evaluation of Cytotoxic and Mutagenic Effects of the Synthetic Cathinones Mexedrone, alpha-PVP and alpha-PHP.
Lenzi M, Cocchi V, Gasperini S, Arfè R, Marti M, Hrelia P. Lenzi M, et al. Int J Mol Sci. 2021 Jun 12;22(12):6320. doi: 10.3390/ijms22126320. Int J Mol Sci. 2021. PMID: 34204826 Free PMC article.
Mexedrone, alpha-PVP and alpha-PHP are synthetic cathinones. They can be considered amphetamine-like substances with a stimulating effect. ...Mexedrone demonstrated its mutagenic potential contrary to the other two compounds; we then proceeded by repeating the analy …
Mexedrone, alpha-PVP and alpha-PHP are synthetic cathinones. They can be considered amphetamine-like substances with a stimula …
Metabolism of alpha-PHP and alpha-PHPP in humans and the effects of alkyl chain lengths on the metabolism of alpha-pyrrolidinophenone-type designer drugs.
Matsuta S, Shima N, Kakehashi H, Kamata H, Nakano S, Sasaki K, Kamata T, Nishioka H, Miki A, Zaitsu K, Tsuchihashi H, Katagi M. Matsuta S, et al. Forensic Toxicol. 2018;36(2):486-497. doi: 10.1007/s11419-018-0428-7. Epub 2018 May 28. Forensic Toxicol. 2018. PMID: 29963212 Free PMC article.
Quantitative analysis indicated oxidation of the pyrrolidine ring to be the major metabolic pathway for alpha-PHP (side chain R: hexyl), but omega or omega-1 oxidation was the major metabolic pathway for alpha-PHPP (R: heptyl). ...In addition, to the best of our kno …
Quantitative analysis indicated oxidation of the pyrrolidine ring to be the major metabolic pathway for alpha-PHP (side chain …
66 results