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Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells.
Parihar MS, Parihar A, Fujita M, Hashimoto M, Ghafourifar P. Parihar MS, et al. Int J Biochem Cell Biol. 2009 Oct;41(10):2015-24. doi: 10.1016/j.biocel.2009.05.008. Epub 2009 May 19. Int J Biochem Cell Biol. 2009. PMID: 19460457
Overexpression of alpha-synuclein and oxidative stress has been implicated in the neuronal cell death in Parkinson's disease. ...Cell Mol Life Sci. 2008a;65:1272-1284]. The present study shows that overexpression of
Overexpression of alpha-synuclein and oxidative stress has been implicated in the neuronal cell de
Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.
Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs AM, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu LA, Lee J, Rochet JC, Khalimonchuk O, Franco R. Anandhan A, et al. Neurobiol Dis. 2015 Sep;81:76-92. doi: 10.1016/j.nbd.2014.11.018. Epub 2014 Dec 8. Neurobiol Dis. 2015. PMID: 25497688 Free PMC article.
However, alpha-synuclein overexpression had no effect on Cu-induced oxidative stress. WT or A53T alpha-synuclein overexpression exacerbated Cu toxicity in dopaminergic and yeast cells in the absence of alpha
However, alpha-synuclein overexpression had no effect on Cu-induced oxidative stress. WT or A53T alpha