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Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes.
Taïb B, Bouyakdan K, Hryhorczuk C, Rodaros D, Fulton S, Alquier T. Taïb B, et al. J Biol Chem. 2013 Dec 27;288(52):37216-29. doi: 10.1074/jbc.M113.506238. Epub 2013 Nov 15. J Biol Chem. 2013. PMID: 24240094 Free PMC article.
α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility.
Fisette A, Tobin S, Décarie-Spain L, Bouyakdan K, Peyot ML, Madiraju SRM, Prentki M, Fulton S, Alquier T. Fisette A, et al. Cell Rep. 2016 Oct 25;17(5):1217-1226. doi: 10.1016/j.celrep.2016.10.004. Cell Rep. 2016. PMID: 27783937
Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons.
Fernandes MF, Matthys D, Hryhorczuk C, Sharma S, Mogra S, Alquier T, Fulton S. Fernandes MF, et al. Cell Metab. 2015 Oct 6;22(4):741-9. doi: 10.1016/j.cmet.2015.08.003. Epub 2015 Sep 1. Cell Metab. 2015. PMID: 26341832
Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.
Alquier T, Kawashima J, Tsuji Y, Kahn BB. Alquier T, et al. Endocrinology. 2007 Mar;148(3):1367-75. doi: 10.1210/en.2006-1039. Epub 2006 Dec 21. Endocrinology. 2007. PMID: 17185376
Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Kawashima J, et al. PLoS One. 2012;7(5):e36335. doi: 10.1371/journal.pone.0036335. Epub 2012 May 10. PLoS One. 2012. PMID: 22590531 Free PMC article.
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.
Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Martin TL, et al. J Biol Chem. 2006 Jul 14;281(28):18933-41. doi: 10.1074/jbc.M512831200. Epub 2006 May 10. J Biol Chem. 2006. PMID: 16687413
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. Minokoshi Y, et al. Nature. 2004 Apr 1;428(6982):569-74. doi: 10.1038/nature02440. Nature. 2004. PMID: 15058305
PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids.
Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL. Oropeza D, et al. Mol Metab. 2015 Aug 14;4(11):811-22. doi: 10.1016/j.molmet.2015.08.001. eCollection 2015 Nov. Mol Metab. 2015. PMID: 26629405 Free PMC article.
An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.
Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. Priyadarshini M, et al. Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Mol Endocrinol. 2015. PMID: 26075576 Free PMC article.
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