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Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.
Cheedipudi SM, Matkovich SJ, Coarfa C, Hu X, Robertson MJ, Sweet M, Taylor M, Mestroni L, Cleveland J, Willerson JT, Gurha P, Marian AJ. Cheedipudi SM, et al. Circ Res. 2019 Apr 12;124(8):1198-1213. doi: 10.1161/CIRCRESAHA.118.314177. Circ Res. 2019. PMID: 30739589 Free PMC article.
CONCLUSIONS: LADs encompass 20% of the genome in human cardiac myocytes comprised several hundred coding and noncoding genes. LADs are redistributed in LMNA-associated DCM in association with markedly altered CpG methylation and gene expression. Thus, …
CONCLUSIONS: LADs encompass 20% of the genome in human cardiac myocytes comprised several hundred coding and noncoding genes. …
DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure.
Pepin ME, Drakos S, Ha CM, Tristani-Firouzi M, Selzman CH, Fang JC, Wende AR, Wever-Pinzon O. Pepin ME, et al. Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H674-H684. doi: 10.1152/ajpheart.00016.2019. Epub 2019 Jul 12. Am J Physiol Heart Circ Physiol. 2019. PMID: 31298559 Free PMC article.
These preliminary observations are the first to uncover an etiology-independent shift in cardiac DNA methylation that corresponds with altered metabolic gene expression in HF.NEW & NOTEWORTHY The failing heart undergoes profound metabolic ch …
These preliminary observations are the first to uncover an etiology-independent shift in cardiac DNA methylation that c …
Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy.
Jo BS, Koh IU, Bae JB, Yu HY, Jeon ES, Lee HY, Kim JJ, Choi M, Choi SS. Jo BS, et al. Genomics. 2016 Aug;108(2):84-92. doi: 10.1016/j.ygeno.2016.07.001. Epub 2016 Jul 12. Genomics. 2016. PMID: 27417303 Free article.
Dilated cardiomyopathy (DCM) is one of the main causes of heart failure (called cardiomyopathies) in adults. Alterations in epigenetic regulation (i.e., DNA methylation) have been implicated in the development of DCM. ...
Dilated cardiomyopathy (DCM) is one of the main causes of heart failure (called cardiomyopathies) in adults. Alterat
Alterations in cardiac DNA methylation in human dilated cardiomyopathy.
Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B. Haas J, et al. EMBO Mol Med. 2013 Mar;5(3):413-29. doi: 10.1002/emmm.201201553. Epub 2013 Jan 22. EMBO Mol Med. 2013. PMID: 23341106 Free PMC article.
Hence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may interact with environmental stimuli. In the present study, we examined genome-wide cardiac DNA methylation in patients wit …
Hence, disease mechanisms must exist that modify the occurrence and progression of DCM, either by genetic or epigenetic factors that may int …
Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes.
Glezeva N, Moran B, Collier P, Moravec CS, Phelan D, Donnellan E, Russell-Hallinan A, O'Connor DP, Gallagher WM, Gallagher J, McDonald K, Ledwidge M, Baugh J, Das S, Watson CJ. Glezeva N, et al. Circ Heart Fail. 2019 Mar;12(3):e005765. doi: 10.1161/CIRCHEARTFAILURE.118.005765. Circ Heart Fail. 2019. PMID: 30798618
BACKGROUND: Limited knowledge exists of the extent of epigenetic alterations, such as DNA methylation, in heart failure (HF). We conducted targeted DNA methylation sequencing to identify DNA methylation alterations in …
BACKGROUND: Limited knowledge exists of the extent of epigenetic alterations, such as DNA methylation, in heart
Data of methylome and transcriptome derived from human dilated cardiomyopathy.
Jo BS, Koh IU, Bae JB, Yu HY, Jeon ES, Lee HY, Kim JJ, Choi M, Choi SS. Jo BS, et al. Data Brief. 2016 Sep 14;9:382-387. doi: 10.1016/j.dib.2016.09.006. eCollection 2016 Dec. Data Brief. 2016. PMID: 27699191 Free PMC article.
Alterations in DNA methylation and gene expression have been implicated in the development of human dilated cardiomyopathy (DCM). ...The data in this DiB are for supporting our report entitled "Methylome analysis reveals alterations
Alterations in DNA methylation and gene expression have been implicated in the development of human dilated
TLR2-ICAM1-Gadd45alpha axis mediates the epigenetic effect of selenium on DNA methylation and gene expression in Keshan disease.
Yang G, Zhu Y, Dong X, Duan Z, Niu X, Wei J. Yang G, et al. Biol Trace Elem Res. 2014 Jun;159(1-3):69-80. doi: 10.1007/s12011-014-9985-8. Epub 2014 May 9. Biol Trace Elem Res. 2014. PMID: 24811888
Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology, and selenium deficiency is considered the main cause of KD. Several observations implicate a role for altered DNA methylation in selenium deficiency-related diseases. T …
Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology, and selenium deficiency is considered the main ca …
Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis.
Koczor CA, Lee EK, Torres RA, Boyd A, Vega JD, Uppal K, Yuan F, Fields EJ, Samarel AM, Lewis W. Koczor CA, et al. Physiol Genomics. 2013 Jul 15;45(14):597-605. doi: 10.1152/physiolgenomics.00013.2013. Epub 2013 May 21. Physiol Genomics. 2013. PMID: 23695888 Free PMC article.
Human dilated cardiomyopathy (DCM) is characterized by congestive heart failure and altered myocardial gene expression. ...Clinical human DCM and nonfailing control left ventricle samples were individually analyzed for DNA methy
Human dilated cardiomyopathy (DCM) is characterized by congestive heart failure and altered myocardial ge
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
Wu TT, Ma YW, Zhang X, Dong W, Gao S, Wang JZ, Zhang LF, Lu D. Wu TT, et al. Lab Invest. 2020 Jul;100(7):974-985. doi: 10.1038/s41374-020-0402-y. Epub 2020 Feb 12. Lab Invest. 2020. PMID: 32051532 Free PMC article.
Among epigenetic marks, the role of DNA hypomethylation in shaping heart morphology and function in vivo and the pathogenesis of cardiomyopathy and/or HF, especially in adults, has not been clearly established. ...The present study is the first to investigate …
Among epigenetic marks, the role of DNA hypomethylation in shaping heart morphology and function in vivo and the pathogenesis …
Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8(+) T and NK Cells in Heart Transplant Patients.
Díaz-Molina B, Diaz-Bulnes P, Carvajal Palao R, Bernardo MJ, Rodriguez RM, Corte-Iglesias V, Moris de la Tassa C, Lambert JL, Suarez-Alvarez B. Díaz-Molina B, et al. Front Immunol. 2018 Sep 26;9:2181. doi: 10.3389/fimmu.2018.02181. eCollection 2018. Front Immunol. 2018. PMID: 30319636 Free PMC article.
The positive long-term effects of conversion to everolimus (EVL) after heart transplantation (HT) have been evaluated in several studies. ...We show that early EVL conversion from MMF allows the increase of cytotoxic (CD56(dim) CD16(+)) NK and effector-memory (EM, CD45RA(- …
The positive long-term effects of conversion to everolimus (EVL) after heart transplantation (HT) have been evaluated in several stud …
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