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Alternative polyadenylation: methods, mechanism, function, and role in cancer.
Zhang Y, Liu L, Qiu Q, Zhou Q, Ding J, Lu Y, Liu P. Zhang Y, et al. J Exp Clin Cancer Res. 2021 Feb 1;40(1):51. doi: 10.1186/s13046-021-01852-7. J Exp Clin Cancer Res. 2021. PMID: 33526057 Free PMC article. Review.
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3'ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a single gene. ...Recent studies have revealed various APA regul …
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3'ends, …
PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma.
Giuliani V, Miller MA, Liu CY, Hartono SR, Class CA, Bristow CA, Suzuki E, Sanz LA, Gao G, Gay JP, Feng N, Rose JL, Tomihara H, Daniele JR, Peoples MD, Bardenhagen JP, Geck Do MK, Chang QE, Vangamudi B, Vellano C, Ying H, Deem AK, Do KA, Genovese G, Marszalek JR, Kovacs JJ, Kim M, Fleming JB, Guccione E, Viale A, Maitra A, Emilia Di Francesco M, Yap TA, Jones P, Draetta G, Carugo A, Chedin F, Heffernan TP. Giuliani V, et al. Nat Commun. 2021 Jul 30;12(1):4626. doi: 10.1038/s41467-021-24798-y. Nat Commun. 2021. PMID: 34330913 Free PMC article.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-derived PDAC model …
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an …
A comprehensive map of alternative polyadenylation in African American and European American lung cancer patients.
Zingone A, Sinha S, Ante M, Nguyen C, Daujotyte D, Bowman ED, Sinha N, Mitchell KA, Chen Q, Yan C, Loher P, Meerzaman D, Ruppin E, Ryan BM. Zingone A, et al. Nat Commun. 2021 Sep 23;12(1):5605. doi: 10.1038/s41467-021-25763-5. Nat Commun. 2021. PMID: 34556645 Free PMC article.
Alternative polyadenylation (APA)-regulation of mRNA 3'UTR length by alternating poly(A) site usage-is a key PTM mechanism whose comprehensive analysis in cancer remains an important open challenge. ...Our results indicate that mRNA trans
Alternative polyadenylation (APA)-regulation of mRNA 3'UTR length by alternating poly(A) site usage-is a key PTM
Alternative polyadenylation: An untapped source for prostate cancer biomarkers and therapeutic targets?
Kurozumi A, Lupold SE. Kurozumi A, et al. Asian J Urol. 2021 Oct;8(4):407-415. doi: 10.1016/j.ajur.2021.05.014. Epub 2021 Jun 6. Asian J Urol. 2021. PMID: 34765448 Free PMC article. Review.
OBJECTIVE: To review alternative polyadenylation (APA) as a mechanism of gene regulation and consider potential roles for APA in prostate cancer (PCa) biology and treatment. METHODS: An extensive review of mRNA polyadenylation, APA, and P …
OBJECTIVE: To review alternative polyadenylation (APA) as a mechanism of gene regulation and consider potential roles f …
CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.
Tan S, Zhang M, Shi X, Ding K, Zhao Q, Guo Q, Wang H, Wu Z, Kang Y, Zhu T, Sun J, Zhao X. Tan S, et al. J Exp Clin Cancer Res. 2021 Mar 1;40(1):85. doi: 10.1186/s13046-021-01884-z. J Exp Clin Cancer Res. 2021. PMID: 33648552 Free PMC article.
BACKGROUND: Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3' termini. ...Functional assays, including the cell number, MTT, colony formation and transwell, wer …
BACKGROUND: Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generatio …
NUDT21 inhibits bladder cancer progression through ANXA2 and LIMK2 by alternative polyadenylation.
Xiong M, Chen L, Zhou L, Ding Y, Kazobinka G, Chen Z, Hou T. Xiong M, et al. Theranostics. 2019 Sep 23;9(24):7156-7167. doi: 10.7150/thno.36030. eCollection 2019. Theranostics. 2019. PMID: 31695759 Free PMC article.
Purpose: Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA), and this molecule has been reported to be a tumor suppressor in human cancers. However, neither the role NUDT21 plays in bladder cancer (BC …
Purpose: Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA), and this molecule ha …
Cell Cycle Regulation by Alternative Polyadenylation of CCND1.
Wang Q, He G, Hou M, Chen L, Chen S, Xu A, Fu Y. Wang Q, et al. Sci Rep. 2018 May 1;8(1):6824. doi: 10.1038/s41598-018-25141-0. Sci Rep. 2018. PMID: 29717174 Free PMC article.
Global shortening of 3'UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the role of APA in cancer remains unknown. CCND1 is a proto-oncogene that regulates progression through the G1-S phase of the cel …
Global shortening of 3'UTRs by alternative polyadenylation (APA) has been observed in cancer cells. However, the rol
Environmental influences on RNA processing: Biochemical, molecular and genetic regulators of cellular response.
Pai AA, Luca F. Pai AA, et al. Wiley Interdiscip Rev RNA. 2019 Jan;10(1):e1503. doi: 10.1002/wrna.1503. Epub 2018 Sep 14. Wiley Interdiscip Rev RNA. 2019. PMID: 30216698 Free PMC article. Review.
Recent work has uncovered extensive remodeling of transcriptome composition upon environmental perturbation and linked the impacts of this molecular plasticity to health and disease outcomes. These isoform changes and their underlying mechanisms are varied-involving alt
Recent work has uncovered extensive remodeling of transcriptome composition upon environmental perturbation and linked the impacts of this m …
Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF-mediated pathway.
Ju H, Mao L, Zhang L, Liu S, Wu Y, Ruan M, Hu J, Ren G. Ju H, et al. J Oral Pathol Med. 2018 Nov;47(10):964-971. doi: 10.1111/jop.12774. Epub 2018 Sep 11. J Oral Pathol Med. 2018. PMID: 30113726
However, little has been known about the change in chemo-sensitivity after hyperthermia and the mechanism underlie it in oral squamous cell carcinoma. METHODS: The aim of this study was to explore the influence of chemo-sensitivity of CAL-27 and SCC-4 cells by histo …
However, little has been known about the change in chemo-sensitivity after hyperthermia and the mechanism underlie it in oral squamou …
Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries.
Grassi E, Mariella E, Lembo A, Molineris I, Provero P. Grassi E, et al. BMC Bioinformatics. 2016 Oct 18;17(1):423. doi: 10.1186/s12859-016-1254-8. BMC Bioinformatics. 2016. PMID: 27756200 Free PMC article.
BACKGROUND: Post-transcriptional regulation is a complex mechanism that plays a central role in defining multiple cellular identities starting from a common genome. Modifications in the length of 3'UTRs have been found to play an important role in this contex …
BACKGROUND: Post-transcriptional regulation is a complex mechanism that plays a central role in defining multiple cellular ide …
16 results