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Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
Altmann KH, Wartmann M, O'Reilly T. Altmann KH, et al. Biochim Biophys Acta. 2000 May 17;1470(3):M79-91. doi: 10.1016/s0304-419x(00)00009-3. Biochim Biophys Acta. 2000. PMID: 10799747 Review. No abstract available.
The biology and medicinal chemistry of epothilones.
Wartmann M, Altmann KH. Wartmann M, et al. Among authors: altmann kh. Curr Med Chem Anticancer Agents. 2002 Jan;2(1):123-48. doi: 10.2174/1568011023354489. Curr Med Chem Anticancer Agents. 2002. PMID: 12678754 Review.
Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.
O'Reilly T, Wartmann M, Maira SM, Hattenberger M, Vaxelaire J, Muller M, Ferretti S, Buchdunger E, Altmann KH, McSheehy PMJ. O'Reilly T, et al. Among authors: altmann kh. Cancer Chemother Pharmacol. 2005 Apr;55(4):307-317. doi: 10.1007/s00280-004-0913-z. Epub 2004 Oct 26. Cancer Chemother Pharmacol. 2005. PMID: 15723258
Microtubule-stabilizing agents: a growing class of important anticancer drugs.
Altmann KH. Altmann KH. Curr Opin Chem Biol. 2001 Aug;5(4):424-31. doi: 10.1016/s1367-5931(00)00225-8. Curr Opin Chem Biol. 2001. PMID: 11470606 Review.
New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.
Bold G, Altmann KH, Frei J, Lang M, Manley PW, Traxler P, Wietfeld B, Brüggen J, Buchdunger E, Cozens R, Ferrari S, Furet P, Hofmann F, Martiny-Baron G, Mestan J, Rösel J, Sills M, Stover D, Acemoglu F, Boss E, Emmenegger R, Lässer L, Masso E, Roth R, Schlachter C, Vetterli W. Bold G, et al. Among authors: altmann kh. J Med Chem. 2000 Jun 15;43(12):2310-23. doi: 10.1021/jm9909443. J Med Chem. 2000. PMID: 10882357
Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors.
Altmann KH, Fabbro D, Dean NM, Geiger T, Monia BP, Müller M, Nicklin P. Altmann KH, et al. Biochem Soc Trans. 1996 Aug;24(3):630-7. doi: 10.1042/bst0240630. Biochem Soc Trans. 1996. PMID: 8878817 Review. No abstract available.
Inhibition of Cell Growth by Antisense Oligonucleotides Targeting the Growth-Related Protein Kinase c-raf.
Fabbro D, Monia BP, Altmann KH, Geiger T. Fabbro D, et al. Among authors: altmann kh. Methods Mol Med. 2000;35:167-88. doi: 10.1385/1-59259-086-1:167. Methods Mol Med. 2000. PMID: 21390806
Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids.
Altmann KH, Hüsken D, Cuenoud B, García-Echeverría C. Altmann KH, et al. Bioorg Med Chem Lett. 2000 May 1;10(9):929-33. doi: 10.1016/s0960-894x(00)00121-9. Bioorg Med Chem Lett. 2000. PMID: 10853662
Macrolide-based microtubule-stabilizing agents - chemistry and structure-activity relationships.
Pfeiffer B, Kuzniewski CN, Wullschleger C, Altmann KH. Pfeiffer B, et al. Among authors: altmann kh. Top Curr Chem. 2009;286:1-72. doi: 10.1007/128_2008_9. Top Curr Chem. 2009. PMID: 23563610
Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence.
Ziegler A, Luedke GH, Fabbro D, Altmann KH, Stahel RA, Zangemeister-Wittke U. Ziegler A, et al. Among authors: altmann kh. J Natl Cancer Inst. 1997 Jul 16;89(14):1027-36. doi: 10.1093/jnci/89.14.1027. J Natl Cancer Inst. 1997. PMID: 9230884
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