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Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Venuti MC, Stephenson RA, Alvarez R, Bruno JJ, Strosberg AM. Venuti MC, et al. J Med Chem. 1988 Nov;31(11):2136-45. doi: 10.1021/jm00119a014. J Med Chem. 1988. PMID: 2846839
Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils.
Kaneko T, Alvarez R, Ueki IF, Nadel JA. Kaneko T, et al. Cell Signal. 1995 Jul;7(5):527-34. doi: 10.1016/0898-6568(95)00023-i. Cell Signal. 1995. PMID: 8562314
Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors.
Saldou N, Obernolte R, Huber A, Baecker PA, Wilhelm R, Alvarez R, Li B, Xia L, Callan O, Su C, Jarnagin K, Shelton ER. Saldou N, et al. Cell Signal. 1998 Jun;10(6):427-40. doi: 10.1016/s0898-6568(97)00169-1. Cell Signal. 1998. PMID: 9720765
Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).
Venuti MC, Alvarez R, Bruno JJ, Strosberg AM, Gu L, Chiang HS, Massey IJ, Chu N, Fried JH. Venuti MC, et al. J Med Chem. 1988 Nov;31(11):2145-52. doi: 10.1021/jm00119a015. J Med Chem. 1988. PMID: 2846840
A single column method for the assay of adenylate cyclase.
Alvarez R, Daniels DV. Alvarez R, et al. Anal Biochem. 1990 May 15;187(1):98-103. doi: 10.1016/0003-2697(90)90423-7. Anal Biochem. 1990. PMID: 2164795
Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin.
Alvarez R, Eglen RM, Chang LF, Bruno JJ, Artis DR, Kluge AF, Whiting RL. Alvarez R, et al. Prostaglandins. 1991 Aug;42(2):105-19. doi: 10.1016/0090-6980(91)90070-v. Prostaglandins. 1991. PMID: 1775633
The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.
Obernolte R, Bhakta S, Alvarez R, Bach C, Zuppan P, Mulkins M, Jarnagin K, Shelton ER. Obernolte R, et al. Gene. 1993 Jul 30;129(2):239-47. doi: 10.1016/0378-1119(93)90274-7. Gene. 1993. PMID: 8392015
Cloned cDNAs from rat (r) suggest that the PDE IV family comprises four distinct members, designated A, B, C and D. Using RN from a human lymphocytic B-cell line (43D-Cl2), we have isolated a 3.8-kb cDNA by low-stringency screening using a rat PDE IV member B (r-PDE …
Cloned cDNAs from rat (r) suggest that the PDE IV family comprises four distinct members, designated A, B, C and D. Using RN from a h …
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
Venuti MC, Jones GH, Alvarez R, Bruno JJ. Venuti MC, et al. J Med Chem. 1987 Feb;30(2):303-18. doi: 10.1021/jm00385a012. J Med Chem. 1987. PMID: 3027339
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