Alvarez-Erviti L - Search Results

1

Exosome-mediated delivery of siRNA in vitro and in vivo.

El-Andaloussi S, Lee Y, Lakhal-Littleton S, Li J, Seow Y, Gardiner C, Alvarez-Erviti L, Sargent IL, Wood MJ. El-Andaloussi S, et al. Nat Protoc. 2012 Dec;7(12):2112-26. doi: 10.1038/nprot.2012.131. Epub 2012 Nov 15. Nat Protoc. 2012. PMID: 23154783

2

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.

Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Alvarez-Erviti L, et al. Nat Biotechnol. 2011 Apr;29(4):341-5. doi: 10.1038/nbt.1807. Epub 2011 Mar 20. Nat Biotechnol. 2011. PMID: 21423189

3

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM. Alvarez-Erviti L, et al. Neurobiol Dis. 2011 Jun;42(3):360-7. doi: 10.1016/j.nbd.2011.01.029. Epub 2011 Feb 18. Neurobiol Dis. 2011. PMID: 21303699 Free PMC article.

4

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice.

Cooper JM, Wiklander PB, Nordin JZ, Al-Shawi R, Wood MJ, Vithlani M, Schapira AH, Simons JP, El-Andaloussi S, Alvarez-Erviti L. Cooper JM, et al. Mov Disord. 2014 Oct;29(12):1476-85. doi: 10.1002/mds.25978. Epub 2014 Aug 11. Mov Disord. 2014. PMID: 25112864 Free PMC article.

5

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting.

Wiklander OP, Nordin JZ, O'Loughlin A, Gustafsson Y, Corso G, Mäger I, Vader P, Lee Y, Sork H, Seow Y, Heldring N, Alvarez-Erviti L, Smith CI, Le Blanc K, Macchiarini P, Jungebluth P, Wood MJ, Andaloussi SE. Wiklander OP, et al. J Extracell Vesicles. 2015 Apr 20;4:26316. doi: 10.3402/jev.v4.26316. eCollection 2015. J Extracell Vesicles. 2015. PMID: 25899407 Free PMC article.

6

Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.

Izco M, Blesa J, Schleef M, Schmeer M, Porcari R, Al-Shawi R, Ellmerich S, de Toro M, Gardiner C, Seow Y, Reinares-Sebastian A, Forcen R, Simons JP, Bellotti V, Cooper JM, Alvarez-Erviti L. Izco M, et al. Mol Ther. 2019 Dec 4;27(12):2111-2122. doi: 10.1016/j.ymthe.2019.08.010. Epub 2019 Aug 27. Mol Ther. 2019. PMID: 31501034 Free PMC article.

7

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line.

Alvarez-Erviti L, Couch Y, Richardson J, Cooper JM, Wood MJ. Alvarez-Erviti L, et al. Neurosci Res. 2011 Apr;69(4):337-42. doi: 10.1016/j.neures.2010.12.020. Epub 2011 Jan 19. Neurosci Res. 2011. PMID: 21255620

8

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation.

Couch Y, Alvarez-Erviti L, Sibson NR, Wood MJ, Anthony DC. Couch Y, et al. J Neuroinflammation. 2011 Nov 28;8:166. doi: 10.1186/1742-2094-8-166. J Neuroinflammation. 2011. PMID: 22122884 Free PMC article.

9

Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.

Alvarez-Erviti L, Seow Y, Schapira AH, Rodriguez-Oroz MC, Obeso JA, Cooper JM. Alvarez-Erviti L, et al. Cell Death Dis. 2013 Mar 14;4(3):e545. doi: 10.1038/cddis.2013.73. Cell Death Dis. 2013. PMID: 23492776 Free PMC article.

10

siRNA Loaded-Exosomes.

Izco M, Alvarez-Erviti L. Izco M, et al. Among authors: alvarez erviti l. Methods Mol Biol. 2021;2282:395-401. doi: 10.1007/978-1-0716-1298-9_21. Methods Mol Biol. 2021. PMID: 33928586

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