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1,377 results

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Page 1
The Gut Microbiota and Alzheimer's Disease.
Jiang C, Li G, Huang P, Liu Z, Zhao B. Jiang C, et al. J Alzheimers Dis. 2017;58(1):1-15. doi: 10.3233/JAD-161141. J Alzheimers Dis. 2017. PMID: 28372330 Review.
The gut microbiota comprises a complex community of microorganism species that resides in our gastrointestinal ecosystem and whose alterations influence not only various gut disorders but also central nervous system disorders such as Alzheimer's disease (AD). …
The gut microbiota comprises a complex community of microorganism species that resides in our gastrointestinal ecosystem and whose alteratio …
Lipids and Alzheimer's Disease.
Kao YC, Ho PC, Tu YK, Jou IM, Tsai KJ. Kao YC, et al. Int J Mol Sci. 2020 Feb 22;21(4):1505. doi: 10.3390/ijms21041505. Int J Mol Sci. 2020. PMID: 32098382 Free PMC article. Review.
Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain is highly enriched in lipids, and disruption of lipid homeostasis is related to neurologic disorders as well as neurodegenerative diseases s …
Lipids, as the basic component of cell membranes, play an important role in human health as well as brain function. The brain …
Creatine Supplementation and Brain Health.
Roschel H, Gualano B, Ostojic SM, Rawson ES. Roschel H, et al. Nutrients. 2021 Feb 10;13(2):586. doi: 10.3390/nu13020586. Nutrients. 2021. PMID: 33578876 Free PMC article. Review.
There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain creatine deficits, which could be induced by acute stressors (e.g., exercise, sleep deprivation) or chronic, pathologic conditions (e.g., crea …
There is a potential for creatine supplementation to improve cognitive processing, especially in conditions characterized by brain cr …
Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease.
Kesika P, Suganthy N, Sivamaruthi BS, Chaiyasut C. Kesika P, et al. Life Sci. 2021 Jan 1;264:118627. doi: 10.1016/j.lfs.2020.118627. Epub 2020 Oct 22. Life Sci. 2021. PMID: 33169684 Review.
Alzheimer's disease (AD) is the most common form of dementia affecting the older person, characterized by beta-amyloid (Abeta) plaques and neurofibrillary tangles leading to the cognitive deficit and memory impairment. Multiple experimental and clinical studi …
Alzheimer's disease (AD) is the most common form of dementia affecting the older person, characterized by beta-amyloid …
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression.
Shi T, Shen S, Shi Y, Wang Q, Zhang G, Lin J, Chen J, Bai F, Zhang L, Wang Y, Gong W, Shao X, Chen G, Yan W, Chen X, Ma Y, Zheng L, Qin J, Lu K, Liu N, Xu Y, Shi YS, Jiang Q, Guo B. Shi T, et al. Nat Metab. 2024 Mar;6(3):531-549. doi: 10.1038/s42255-024-00989-x. Epub 2024 Feb 26. Nat Metab. 2024. PMID: 38409606
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's disease (AD). ...Here we show that osteocyte-derived sclerostin can cross the blood-brain barrier of old mice, where it can dysregulate Wnt-beta-ca …
Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's disease (AD). ...Here we sho …
Peripheral and central neuroimmune mechanisms in Alzheimer's disease pathogenesis.
Zhang S, Gao Y, Zhao Y, Huang TY, Zheng Q, Wang X. Zhang S, et al. Mol Neurodegener. 2025 Feb 21;20(1):22. doi: 10.1186/s13024-025-00812-5. Mol Neurodegener. 2025. PMID: 39985073 Free PMC article. Review.
Alzheimer's disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain barrier disruption allows per …
Alzheimer's disease (AD) poses a growing global health challenge as populations age. Recent research highlights the cru …
Alzheimer's Disease and Vascular Aging: JACC Focus Seminar.
Cortes-Canteli M, Iadecola C. Cortes-Canteli M, et al. J Am Coll Cardiol. 2020 Mar 3;75(8):942-951. doi: 10.1016/j.jacc.2019.10.062. J Am Coll Cardiol. 2020. PMID: 32130930 Free PMC article. Review.
Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain. ...Although the molecular pathogenesis of these alterations r …
Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative condition characterized by ac …
Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease.
Pugazhenthi S, Qin L, Reddy PH. Pugazhenthi S, et al. Biochim Biophys Acta Mol Basis Dis. 2017 May;1863(5):1037-1045. doi: 10.1016/j.bbadis.2016.04.017. Epub 2016 May 6. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27156888 Free PMC article. Review.
Diabetes and obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most common form of dementia. Studies have identified several overlapping neurodegenerative mechanisms, including oxidative stress, mitochondrial dysfunction, and inf …
Diabetes and obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most common form of dement …
Blood-Brain Barrier Dysfunction in Normal Aging and Neurodegeneration: Mechanisms, Impact, and Treatments.
Andjelkovic AV, Situ M, Citalan-Madrid AF, Stamatovic SM, Xiang J, Keep RF. Andjelkovic AV, et al. Stroke. 2023 Mar;54(3):661-672. doi: 10.1161/STROKEAHA.122.040578. Epub 2023 Feb 27. Stroke. 2023. PMID: 36848419 Free PMC article. Review.
Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brain barrier (BBB). The endothelium is regulated by perivascular cells and components forming the neurovascular unit. This review ex …
Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-functional interface, the blood-brai …
Rapid amyloid-beta clearance and cognitive recovery through multivalent modulation of blood-brain barrier transport.
Chen J, Xiang P, Duro-Castano A, Cai H, Guo B, Liu X, Yu Y, Lui S, Luo K, Ke B, Ruiz-Pérez L, Gong Q, Tian X, Battaglia G. Chen J, et al. Signal Transduct Target Ther. 2025 Oct 7;10(1):331. doi: 10.1038/s41392-025-02426-1. Signal Transduct Target Ther. 2025. PMID: 41052971 Free PMC article.
The blood-brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous system (CNS) from potentially harmful substances while regulating the transport of essential molecules. Its dysfunction is increasingly recogni …
The blood-brain barrier (BBB) is a highly selective permeability barrier that safeguards the central nervous sys …
1,377 results