Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood.
Smith CJ, Ross N, Kamal A, Kim KY, Kropf E, Deschatelets P, Francois C, Quinn WJ 3rd, Singh I, Majowicz A, Mingozzi F, Kuranda K.
Smith CJ, et al.
Front Immunol. 2022 Sep 16;13:999021. doi: 10.3389/fimmu.2022.999021. eCollection 2022.
Front Immunol. 2022.
PMID: 36189251
Free PMC article.
Interestingly, both full and empty viral particles were equally potent in inducing complement activation and cytokine secretion. By using a compstatin-based C3 and C3b inhibitor, APL-9, we demonstrated that complement pathway inhibition lowered CD86 levels on APCs, AAV upt …
Interestingly, both full and empty viral particles were equally potent in inducing complement activation and cytokine secretion. By using a …