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Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor.
Ohno K, Amano Y, Kakuta H, Niimi T, Takakura S, Orita M, Miyata K, Sakashita H, Takeuchi M, Komuro I, Higaki J, Horiuchi M, Kim-Mitsuyama S, Mori Y, Morishita R, Yamagishi S. Ohno K, et al. Among authors: amano y. Biochem Biophys Res Commun. 2011 Jan 7;404(1):434-7. doi: 10.1016/j.bbrc.2010.11.139. Epub 2010 Dec 3. Biochem Biophys Res Commun. 2011. PMID: 21130741
Advances in fragment-based drug discovery platforms.
Orita M, Warizaya M, Amano Y, Ohno K, Niimi T. Orita M, et al. Among authors: amano y. Expert Opin Drug Discov. 2009 Nov;4(11):1125-44. doi: 10.1517/17460440903317580. Expert Opin Drug Discov. 2009. PMID: 23480433
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