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Page 1
Homocysteine and Age-Related Central Nervous System Diseases: Role of Inflammation.
Tawfik A, Elsherbiny NM, Zaidi Y, Rajpurohit P. Tawfik A, et al. Int J Mol Sci. 2021 Jun 10;22(12):6259. doi: 10.3390/ijms22126259. Int J Mol Sci. 2021. PMID: 34200792 Free PMC article. Review.
The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and eye diseases, and age-related macular degeneration (AMD) and diabetic retinopathy (DR) in elderly people, has been established. ...
The relation between HHcy and the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and eye diseases, and age …
Implication of N-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration.
Samra YA, Kira D, Rajpurohit P, Mohamed R, Owen LA, Shakoor A, Kim IK, DeAngelis MM, Sheibani N, Al-Shabrawey M, Tawfik A. Samra YA, et al. Among authors: tawfik a. Int J Mol Sci. 2021 Aug 28;22(17):9356. doi: 10.3390/ijms22179356. Int J Mol Sci. 2021. PMID: 34502266 Free PMC article.
Age-related macular degeneration (AMD) is a leading cause of vision loss. Elevated homocysteine (Hcy) (Hyperhomocysteinemia) (HHcy) has been reported in AMD. ...
Age-related macular degeneration (AMD) is a leading cause of vision loss. Elevated homocysteine (Hcy) (Hyperhomo …
Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration.
Ibrahim AS, Mander S, Hussein KA, Elsherbiny NM, Smith SB, Al-Shabrawey M, Tawfik A. Ibrahim AS, et al. Among authors: tawfik a. Oncotarget. 2016 Feb 23;7(8):8532-45. doi: 10.18632/oncotarget.7384. Oncotarget. 2016. PMID: 26885895 Free PMC article.
The disruption of retinal pigment epithelial (RPE) function and the degeneration of photoreceptors are cardinal features of age related macular degeneration (AMD); however there are still gaps in our understanding of underlying biological proces …
The disruption of retinal pigment epithelial (RPE) function and the degeneration of photoreceptors are cardinal features of age …
Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration.
Elmasry K, Mohamed R, Sharma I, Elsherbiny NM, Liu Y, Al-Shabrawey M, Tawfik A. Elmasry K, et al. Among authors: tawfik a. Oncotarget. 2018 Jan 29;9(16):12562-12590. doi: 10.18632/oncotarget.24333. eCollection 2018 Feb 27. Oncotarget. 2018. PMID: 29560091 Free PMC article.
Hcy-induced epigenetic modifications may be involved in retinopathies associated with HHcy, such as age-related macular degeneration and diabetic retinopathy....
Hcy-induced epigenetic modifications may be involved in retinopathies associated with HHcy, such as age-related macular …
Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction.
Tawfik A, Samra YA, Elsherbiny NM, Al-Shabrawey M. Tawfik A, et al. Biomolecules. 2020 Jul 29;10(8):1119. doi: 10.3390/biom10081119. Biomolecules. 2020. PMID: 32751132 Free PMC article. Review.
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has been linked to different systemic and neurological diseases, well-known as a risk factor for systemic atherosclerosis and cardiovascular disease (CVD) and has been identified as a risk factor for s …
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has been linked to different systemic and neurological diseas …
Homocysteine Induces Inflammation in Retina and Brain.
Elsherbiny NM, Sharma I, Kira D, Alhusban S, Samra YA, Jadeja R, Martin P, Al-Shabrawey M, Tawfik A. Elsherbiny NM, et al. Among authors: tawfik a. Biomolecules. 2020 Mar 3;10(3):393. doi: 10.3390/biom10030393. Biomolecules. 2020. PMID: 32138265 Free PMC article.
Vitamins B(12) and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic retinopathy (DR), age-related macular degeneration (AMD), and Alzheimer's disease (AD). The goal of the current …
Vitamins B(12) and folic acid deficiencies lead to hyperhomocysteinemia (HHcy, elevated Hcy), which is linked to the development of diabetic …
N-Methyl-D-aspartate receptor activation, novel mechanism of homocysteine-induced blood-retinal barrier dysfunction.
Tawfik A, Mohamed R, Kira D, Alhusban S, Al-Shabrawey M. Tawfik A, et al. J Mol Med (Berl). 2021 Jan;99(1):119-130. doi: 10.1007/s00109-020-02000-y. Epub 2020 Nov 6. J Mol Med (Berl). 2021. PMID: 33159240 Free PMC article.
Elevated levels of amino acid homocysteine (Hcy) recognized as hyperhomocysteinemia (HHcy) was reported in several human visual disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of blood-retinal barrier …
Elevated levels of amino acid homocysteine (Hcy) recognized as hyperhomocysteinemia (HHcy) was reported in several human visual disorders, s …
Exacerbation of AMD Phenotype in Lasered CNV Murine Model by Dysbiotic Oral Pathogens.
Arjunan P, Swaminathan R, Yuan J, Elashiry M, Tawfik A, Al-Shabrawey M, Martin PM, Muthusamy T, Cutler CW. Arjunan P, et al. Among authors: tawfik a. Antioxidants (Basel). 2021 Feb 18;10(2):309. doi: 10.3390/antiox10020309. Antioxidants (Basel). 2021. PMID: 33670526 Free PMC article.
Emerging evidence underscores an association between age-related macular degeneration (AMD) and periodontal disease (PD), yet the biological basis of this linkage and the specific role of oral dysbiosis caused by PD in AMD pathophysiology remains uncle …
Emerging evidence underscores an association between age-related macular degeneration (AMD) and periodontal dise …
Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress.
Mohamed R, Sharma I, Ibrahim AS, Saleh H, Elsherbiny NM, Fulzele S, Elmasry K, Smith SB, Al-Shabrawey M, Tawfik A. Mohamed R, et al. Among authors: tawfik a. Sci Rep. 2017 Sep 20;7(1):11952. doi: 10.1038/s41598-017-09731-y. Sci Rep. 2017. PMID: 28931831 Free PMC article.
Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of the blood-retinal barrier (BRB) is linked to vision loss in DR and AMD. ...
Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as diabetic retinopathy (DR) and age-related …
Targeting Neovascularization in Ischemic Retinopathy: Recent Advances.
Al-Shabrawey M, Elsherbiny M, Nussbaum J, Othman A, Megyerdi S, Tawfik A. Al-Shabrawey M, et al. Among authors: tawfik a. Expert Rev Ophthalmol. 2013 Jun;8(3):267-286. doi: 10.1586/eop.13.17. Expert Rev Ophthalmol. 2013. PMID: 25598837 Free PMC article.
Pathological retinal neovascularization (RNV) is a common micro-vascular complication in several retinal diseases including retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration and central vein occlusion. The current thera …
Pathological retinal neovascularization (RNV) is a common micro-vascular complication in several retinal diseases including retinopathy of p …