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Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.
Persson L, Cao G, Ståhle L, Sjöberg BG, Troutt JS, Konrad RJ, Gälman C, Wallén H, Eriksson M, Hafström I, Lind S, Dahlin M, Amark P, Angelin B, Rudling M. Persson L, et al. Among authors: amark p. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2666-72. doi: 10.1161/ATVBAHA.110.214130. Epub 2010 Sep 30. Arterioscler Thromb Vasc Biol. 2010. PMID: 20884874 Clinical Trial.
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