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Eccentric muscle contraction and stretching evoke mechanical hyperalgesia and modulate CGRP and P2X(3) expression in a functionally relevant manner.
Dessem D, Ambalavanar R, Evancho M, Moutanni A, Yallampalli C, Bai G. Dessem D, et al. Among authors: ambalavanar r. Pain. 2010 May;149(2):284-95. doi: 10.1016/j.pain.2010.02.022. Epub 2010 Mar 5. Pain. 2010. PMID: 20207080 Free PMC article.
Inflammation of craniofacial muscle induces widespread mechanical allodynia.
Ambalavanar R, Moutanni A, Dessem D. Ambalavanar R, et al. Neurosci Lett. 2006 May 22;399(3):249-54. doi: 10.1016/j.neulet.2006.02.003. Epub 2006 Feb 28. Neurosci Lett. 2006. PMID: 16510243
Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist.
Ambalavanar R, Moritani M, Moutanni A, Gangula P, Yallampalli C, Dessem D. Ambalavanar R, et al. Pain. 2006 Jan;120(1-2):53-68. doi: 10.1016/j.pain.2005.10.003. Epub 2005 Dec 13. Pain. 2006. PMID: 16359792
Emerging peripheral receptor targets for deep-tissue craniofacial pain therapies.
Ambalavanar R, Dessem D. Ambalavanar R, et al. J Dent Res. 2009 Mar;88(3):201-11. doi: 10.1177/0022034508330176. J Dent Res. 2009. PMID: 19329451 Free PMC article. Review.
Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior.
Ambalavanar R, Dessem D, Moutanni A, Yallampalli C, Yallampalli U, Gangula P, Bai G. Ambalavanar R, et al. Neuroscience. 2006 Dec;143(3):875-84. doi: 10.1016/j.neuroscience.2006.08.015. Epub 2006 Oct 4. Neuroscience. 2006. PMID: 17027165
Injection of adjuvant but not acidic saline into craniofacial muscle evokes nociceptive behaviors and neuropeptide expression.
Ambalavanar R, Yallampalli C, Yallampalli U, Dessem D. Ambalavanar R, et al. Neuroscience. 2007 Nov 9;149(3):650-9. doi: 10.1016/j.neuroscience.2007.07.058. Epub 2007 Sep 8. Neuroscience. 2007. PMID: 17928159 Free PMC article.
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