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Genetic immunization against neu/erbB2 transgenic breast cancer.
Amici A, Venanzi FM, Concetti A. Amici A, et al. Cancer Immunol Immunother. 1998 Dec;47(4):183-90. doi: 10.1007/s002620050519. Cancer Immunol Immunother. 1998. PMID: 9875670
erbB2/neu, an overexpressed oncogene product, has been proposed as a human cancer vaccine target. In the present study, transgenic (rat neuNT oncogene) FVB/neu mice, developing metastasizable mammary carcinoma, were immunized with a plasmid DNA encoding are not tole …
erbB2/neu, an overexpressed oncogene product, has been proposed as a human cancer vaccine target. In the present study, transgenic (r …
neu/HER-2 cDNA vaccination and pregnancy loss.
Venanzi FM, Petrelli C, Concetti A, Amici A. Venanzi FM, et al. Ann N Y Acad Sci. 1995 Nov 27;772:274-7. doi: 10.1111/j.1749-6632.1995.tb44758.x. Ann N Y Acad Sci. 1995. PMID: 8546407 No abstract available.
Autoantibody to p185erbB2/neu oncoprotein by vaccination with xenogenic DNA.
Concetti A, Amici A, Petrelli C, Tibaldi A, Provinciali M, Venanzi FM. Concetti A, et al. Cancer Immunol Immunother. 1996 Dec;43(5):307-15. doi: 10.1007/s002620050338. Cancer Immunol Immunother. 1996. PMID: 9024508
Binding of feline immunodeficiency viral gag-p24 polypeptide to nonimmune Igs.
Amici A, Smorlesi A, Concetti A, Ripani E, Battistini L, Venanzi FM. Amici A, et al. Immunol Lett. 1998 Jun;62(2):93-7. doi: 10.1016/s0165-2478(98)00033-9. Immunol Lett. 1998. PMID: 9698104
Moreover, FACS scanning experiments are consistent with the possibility that rec.p24 interacts with surface-Ig in a sub-population (5-6%) of rodent B cells. ...
Moreover, FACS scanning experiments are consistent with the possibility that rec.p24 interacts with surface-Ig in a sub-population (5 …
DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Amici A, Smorlesi A, Noce G, Santoni G, Cappelletti P, Capparuccia L, Coppari R, Lucciarini R, Petrelli C, Provinciali M. Amici A, et al. Gene Ther. 2000 Apr;7(8):703-6. doi: 10.1038/sj.gt.3301151. Gene Ther. 2000. PMID: 10800094
The coinjection with a bicistronic vector for murine IL-12 increased the efficacy of pCMV-ECD and pCMV-NeuNT plasmids, and led to the same protection obtained with pCMV-ECD-TM alone. ...Our data demonstrate the effectiveness of DNA vaccination using truncated Neu plasmids …
The coinjection with a bicistronic vector for murine IL-12 increased the efficacy of pCMV-ECD and pCMV-NeuNT plasmids, and led to the …
DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice.
Rovero S, Amici A, Di Carlo E, Bei R, Nanni P, Quaglino E, Porcedda P, Boggio K, Smorlesi A, Lollini PL, Landuzzi L, Colombo MP, Giovarelli M, Musiani P, Forni G. Rovero S, et al. J Immunol. 2000 Nov 1;165(9):5133-42. doi: 10.4049/jimmunol.165.9.5133. J Immunol. 2000. PMID: 11046045
In normal BALB/c mice, DNA vaccination elicits anti-r-p185 Ab, but only a marginal CTL reactivity, and protects against a TUBO cell challenge. ...Tumor-free mammary glands still display the atypical hyperplasia of the early stages of carcinogenesis, and a mar …
In normal BALB/c mice, DNA vaccination elicits anti-r-p185 Ab, but only a marginal CTL reactivity, and protects against a TUBO …
Inhibition of mammary carcinogenesis by systemic interleukin 12 or p185neu DNA vaccination in Her-2/neu transgenic BALB/c mice.
Di Carlo E, Rovero S, Boggio K, Quaglino E, Amici A, Smorlesi A, Forni G, Musiani P. Di Carlo E, et al. Clin Cancer Res. 2001 Mar;7(3 Suppl):830s-837s. Clin Cancer Res. 2001. PMID: 11300480
On the other hand, specific vaccination with plasmids encoding for the rat p185neu resulted in a further delay, so much so that 58% of mice were tumor free at week 33. ...These results suggest that the elicitation of nonspecific and specific immunity could be beneficially …
On the other hand, specific vaccination with plasmids encoding for the rat p185neu resulted in a further delay, so much so that 58% o …
Insertion of the DNA for the 163-171 peptide of IL1beta enables a DNA vaccine encoding p185(neu) to inhibit mammary carcinogenesis in Her-2/neu transgenic BALB/c mice.
Rovero S, Boggio K, Di Carlo E, Amici A, Quaglino E, Porcedda P, Musiani P, Forni G. Rovero S, et al. Gene Ther. 2001 Mar;8(6):447-52. doi: 10.1038/sj.gt.3301416. Gene Ther. 2001. PMID: 11313823
This reduction was associated with a marked immune-inflammatory reaction and a conspicuous leukocyte infiltrate located in the stroma surrounding the hyperplastic mammary ductul-alveolar structures. It was also directly correlated with a high anti-p185(neu) a …
This reduction was associated with a marked immune-inflammatory reaction and a conspicuous leukocyte infiltrate located in the …
Immunological prevention of spontaneous tumors: a new prospect?
Quaglino E, Rovero S, Cavallo F, Musiani P, Amici A, Nicoletti G, Nanni P, Forni G. Quaglino E, et al. Immunol Lett. 2002 Feb 1;80(2):75-9. doi: 10.1016/s0165-2478(01)00323-6. Immunol Lett. 2002. PMID: 11750037
This inhibition is the outcome of a delayed-type hypersensitivity specific for p185neu and the production of anti-p185neu antibodies that restrain the proliferation of tumor cells by stripping p185neu from their membrane, whereas cytotoxic T lymphocytes seem devoid of a
This inhibition is the outcome of a delayed-type hypersensitivity specific for p185neu and the production of anti-p185neu antibodies …
Low effectiveness of DNA vaccination against HER-2/neu in ageing.
Provinciali M, Smorlesi A, Donnini A, Bartozzi B, Amici A. Provinciali M, et al. Vaccine. 2003 Feb 14;21(9-10):843-8. doi: 10.1016/s0264-410x(02)00530-3. Vaccine. 2003. PMID: 12547592
Young and old Balb/c mice received three immunizations with a pCMVneuNT DNA plasmid and, successively, were challenged with TUBO cells. ...We conclude that anticancer DNA vaccination has a lower effectiveness in old than in young ages....
Young and old Balb/c mice received three immunizations with a pCMVneuNT DNA plasmid and, successively, were challenged with TUBO cell …
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