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Page 1
Amiloride: A review.
Sun Q, Sever P. Sun Q, et al. J Renin Angiotensin Aldosterone Syst. 2020 Oct-Dec;21(4):1470320320975893. doi: 10.1177/1470320320975893. J Renin Angiotensin Aldosterone Syst. 2020. PMID: 33234024 Free PMC article. Review.
Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct. Amiloride is indicated in oedematous states, and for potassium conservation adjunc …
Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking luminal epithelial sodium channels (ENa …
Amiloride and calciuria.
Luft FC, Sällström J. Luft FC, et al. Nephrol Dial Transplant. 2022 Jan 25;37(2):205-207. doi: 10.1093/ndt/gfab221. Nephrol Dial Transplant. 2022. PMID: 34264323 No abstract available.
Amiloride alleviates morphine tolerance by suppressing ASIC3-dependent neuroinflammation in the spinal cord.
Gei L, Yan Y, Xing W, Li Q, Chen X, Yan F, Wang Y, Cao Y, Jiang W, E R, Luo D, Zhang Y, Zeng W, Chen D. Gei L, et al. Eur J Pharmacol. 2024 Jan 15;963:176173. doi: 10.1016/j.ejphar.2023.176173. Epub 2023 Oct 31. Eur J Pharmacol. 2024. PMID: 37918499 Free article.
Microglia play a crucial role in the establishment of morphine tolerance. Thus, we anticipated that amiloride might suppress the development of morphine tolerance. During this investigation, we assessed the impact of amiloride on mouse morphine tolerance. ...Further …
Microglia play a crucial role in the establishment of morphine tolerance. Thus, we anticipated that amiloride might suppress the deve …
Amiloride and the Na(+)/H(+) exchanger protein: mechanism and significance of inhibition of the Na(+)/H(+) exchanger (review).
Harris C, Fliegel L. Harris C, et al. Int J Mol Med. 1999 Mar;3(3):315-21. doi: 10.3892/ijmm.3.3.315. Int J Mol Med. 1999. PMID: 10028059 Review.
Amiloride and its derivatives are important tools for studying NHE-1, the ubiquitous isoform of the sodium/hydrogen exchanger protein family. Three residues in putative transmembrane domains IV and IX have been implicated in amiloride binding and several models of t …
Amiloride and its derivatives are important tools for studying NHE-1, the ubiquitous isoform of the sodium/hydrogen exchanger protein …
Allosteric modulation of G protein-coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?
Massink A, Amelia T, Karamychev A, IJzerman AP. Massink A, et al. Med Res Rev. 2020 Mar;40(2):683-708. doi: 10.1002/med.21633. Epub 2019 Sep 8. Med Res Rev. 2020. PMID: 31495942 Free PMC article. Review.
Amiloride analogs with lipophilic substituents tend to be more potent modulators than amiloride itself. Adenosine, alpha-adrenergic and dopamine receptors are most strongly modulated by amiloride analogs. In addition, for a few GPCRs, more than one binding si …
Amiloride analogs with lipophilic substituents tend to be more potent modulators than amiloride itself. Adenosine, alpha-adren …
Stability of extemporaneously compounded amiloride nasal spray.
Yellepeddi V, Sayre C, Burrows A, Watt K, Davies S, Strauss J, Battaglia M. Yellepeddi V, et al. PLoS One. 2020 Jul 10;15(7):e0232435. doi: 10.1371/journal.pone.0232435. eCollection 2020. PLoS One. 2020. PMID: 32649677 Free PMC article.
Therefore, this study reports the formulation, physical, chemical, and microbiological stability of an extemporaneously prepared amiloride 2 mg/mL nasal spray. The amiloride nasal spray was prepared by adding 100 mg of amiloride hydrochloride to 50 mL of ster …
Therefore, this study reports the formulation, physical, chemical, and microbiological stability of an extemporaneously prepared amilorid …
Amiloride Analogs as ASIC1a Inhibitors.
Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Leng TD, et al. CNS Neurosci Ther. 2016 Jun;22(6):468-76. doi: 10.1111/cns.12524. Epub 2016 Feb 18. CNS Neurosci Ther. 2016. PMID: 26890278 Free PMC article.
Surflex-Dock was used to dock the analogs into the pocket with default parameters. RESULTS: Amiloride and its analogs inhibit ASIC1a currents expressed in Chinese hamster ovary cells with a potency rank order of benzamil > phenamil > 5-(N,N-dimethyl)amiloride …
Surflex-Dock was used to dock the analogs into the pocket with default parameters. RESULTS: Amiloride and its analogs inhibit ASIC1a …
Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger.
Frelin C, Barbry P, Vigne P, Chassande O, Cragoe EJ Jr, Lazdunski M. Frelin C, et al. Biochimie. 1988 Sep;70(9):1285-90. doi: 10.1016/0300-9084(88)90196-4. Biochimie. 1988. PMID: 2852509 Review.
Conversely, amiloride derivatives that are substituted on the guanidino moiety, such as phenamil, are potent inhibitors of the epithelium Na+ channel. It is thus possible, by using selected amiloride derivatives to inhibit selectively one or another of the Na+ trans …
Conversely, amiloride derivatives that are substituted on the guanidino moiety, such as phenamil, are potent inhibitors of the epithe …
Capsazepine activates amiloride-insensitive ENaC-like channels in human leukemia cells.
Lysikova DV, Vasileva VY, Chubinskiy-Nadezhdin VI, Morachevskaya EA, Sudarikova AV. Lysikova DV, et al. Biochem Biophys Res Commun. 2023 Dec 20;687:149187. doi: 10.1016/j.bbrc.2023.149187. Epub 2023 Nov 2. Biochem Biophys Res Commun. 2023. PMID: 37944472
Sodium influx carried out by ion channels is one of the main regulators of water-salt and volume balance in cells of blood origin. Previously, we described amiloride-insensitive ENaC-like channels in human myeloid leukemia K562 cells; the intracellular regulatory mechanism …
Sodium influx carried out by ion channels is one of the main regulators of water-salt and volume balance in cells of blood origin. Previousl …
A novel lipophilic amiloride derivative efficiently kills chemoresistant breast cancer cells.
Hu M, Liu R, Castro N, Loza Sanchez L, Rueankham L, Learn JA, Huang R, Lam KS, Carraway KL 3rd. Hu M, et al. Sci Rep. 2024 Aug 31;14(1):20263. doi: 10.1038/s41598-024-71181-0. Sci Rep. 2024. PMID: 39217266 Free PMC article.
However, a major barrier to clinical translation of the amilorides is their modest cytotoxic potency, with estimated IC(50) values in the high micromolar range. ...Nonetheless, our observations offer a roadmap for the future optimization of amiloride-based compounds …
However, a major barrier to clinical translation of the amilorides is their modest cytotoxic potency, with estimated IC(50) values in …
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